INVESTIGADORES
ENRIZ Ricardo Daniel
artículos
Título:
Structure-Activity Relationship of Berberine and Derivatives Acting as Antifungal Compounds
Autor/es:
R.D.ENRIZ, M.L.FEILE
Revista:
Journal of the Argentine Chemical Society
Referencias:
Lugar: Buenos Aires; Año: 2006 vol. 94 p. 113 - 119
ISSN:
0365-0375
Resumen:
Abstract
A structure-activity relationship study of berberine and structurally related
compounds is reported. Berberine, was chemically modified in order to obtain canadine
and oxyberberine. The in vitro evaluation of antifungal activity of berberine, canadine,
oxyberberine, liriodenine, o-methyl-mostachatoline and other four derivatives is also
reported here. Our results allow us to determine the minimal structural requirements to
produce the antifungal response and can provide a guide for the design of new compounds
with these properties.