INVESTIGADORES
ENRIZ Ricardo Daniel
artículos
Título:
Synthesis and Conformational analysis of His-Phe-Arg-Trp-NH2 and analogues with antifungal properties
Autor/es:
MASMAN; A.M.RODRIGUEZ; L.SVETAZ; S.A.ZACHINO; C.SOMLAI; I.G.SCIZMADIA; B.PENKE; R.D.ENRIZ
Revista:
BIOORGANIC & MEDICINAL CHEMISTRY.
Editorial:
Elsevier
Referencias:
Lugar: Amsterdam; Año: 2006 vol. 14 p. 7604 - 7614
ISSN:
0968-0896
Resumen:
Abstract: The synthesis, in vitro evaluation and conformational study of His-Phe-Arg-Trp-NH2 and related
derivatives acting as antifungal agents are reported. Among them, His-Phe-Arg-Trp-NH2 and His-Tyr-Arg-
Trp-NH2 exhibited antifungal activity against Cryptococcus neoformans. Antifungal activity of these
compounds appears to be closely related to the á-MSH effect. A conformational and electronic study allows
us to propose a biologically relevant conformation for these tetrapeptides acting as antifungal agents. In
addition, these theoretical calculations permit us to determine the minimal structural requirements to
produce the antifungal response and may provide a guide for the design of compounds with this biological
activity.á-MSH effect. A conformational and electronic study allows
us to propose a biologically relevant conformation for these tetrapeptides acting as antifungal agents. In
addition, these theoretical calculations permit us to determine the minimal structural requirements to
produce the antifungal response and may provide a guide for the design of compounds with this biological
activity.