INVESTIGADORES
LOPEZ Laura Susana
artículos
Título:
EFFECTS OF SEROTONIN AND FLUOXETINE ON BLOOD GLUCOSE REGULATION IN TWO DECAPOD SPECIES
Autor/es:
SANTOS, E.A., KELLER, R., RODRIGUEZ, E.M. Y L.S. LÓPEZ G
Revista:
BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
Referencias:
Año: 2001 vol. 34 p. 75 - 80
ISSN:
0100-879X
Resumen:
One of the best known crustacean hormones in the crustacean hyperglycemic hormone (CHH). However, the mechanisms involved in hormone release in these animals are poorly understood, and thus constitute the central objective of the present study. Different groups of crustaceans belonging to diverse taxa (Chasmagnathus granulata, a grapsid crab and Orconectes limosus, as astacid) were injected with serotonin, fluoxetine, or a mixture of both, and glycemic values (C. granulata and O. limosus) and CHH levels (O. limosus) were determined after 2 h in either submerged animals or animals exposed to atmosferic air. Both serotonin and fluoxetine caused significant hyperglycemia (p<0.05) after injection into the blood sinus of the two species, an effect enhanced after exposure to atmospheric air. In C. granulata blood glucose increased from 6.1 to 43.3 and 11.4 mg/100 ml in submerged animals and from 5.7 to 55.2 and 22.5 mg/100 ml in air exposed animals after treatment with serotonin and fluoxetine, respectively. Serotonin and fluoxetine also caused a significant increase in the circulating levels of CHH in O. limosus, frm 11.9 to 43 and 45.7 fmol/ml in submerged animals and from 13.2 to 32.6 and 45.7 fmol/ml in air exposed animals, respectively, thus confirming their action as neuroregulatos in these invertebrates.