INVESTIGADORES
KASANETZ Fernando
artículos
Título:
Brain oscillations, medium spiny neurons, and dopamine.
Autor/es:
M. G. MURER, K. Y. TSENG, ; F. KASANETZ,; M. BELLUSCIO, L. A. RIQUELME
Revista:
CELLULAR AND MOLECULAR NEUROBIOLOGY.
Editorial:
SPRINGER/PLENUM PUBLISHERS
Referencias:
Lugar: New York; Año: 2002 vol. 22 p. 611 - 632
ISSN:
0272-4340
Resumen:
1. The striatum is part of a
multisynaptic loop involved in translating higher order cognitive
activity into action. The main striatal computational unit is the medium
spiny neuron, which integrates inputs arriving from widely distributed
cortical neurons and provides the sole striatal output.
2.
The membrane potential of medium spiny neurons' displays shifts between
a very negative resting state (down state) and depolarizing plateaus
(up states) which are driven by the excitatory cortical inputs.
3.
Because striatal spiny neurons fire action potentials only during the
up state, these plateau depolarizations are perceived as enabling events
that allow information processing through cerebral cortex ? basal
ganglia circuits. In vivo intracellular recording techniques allow to
investigate simultaneously the subthreshold behavior of the medium spiny
neuron membrane potential (which is a ?reading? of distributed patterns
of cortical activity) and medium spiny neuron firing (which is an index
of striatal output).
4. Recent studies
combining intracellular recordings of striatal neurons with field
potential recordings of the cerebral cortex illustrate how the analysis
of the input?output transformations performed by medium spiny neurons
may help to unveil some aspects of information processing in cerebral
cortex ? basal ganglia circuits, and to understand the origin of the
clinical manifestations of Parkinson's
disease and other neurologic and neuropsychiatric disorders that result
from alterations in dopamine-dependent information processing in the
cerebral cortex ? basal ganglia circuits.