INVESTIGADORES
SILVA JUNQUEIRA DE SOUZA Flavio
artículos
Título:
The zinc finger gene Xblimp1 controls anterior endomesodermal cell fate in Spemann's organizer.
Autor/es:
DE SOUZA FS; GAWANTKA W; GÓMEZ AP; DELIUS H; ANG SL; NIEHRS C
Revista:
EMBO JOURNAL
Editorial:
NATURE PUBLISHING GROUP
Referencias:
Año: 1999 p. 6062 - 6072
ISSN:
0261-4189
Resumen:
The anterior endomesoderm of the early Xenopus gastrula is a part of Spemann's organizer and is important for head induction. Here we describe Xblimp1, which encodes a zinc finger transcriptional repressor expressed in the anterior endomesoderm. Xblimp1 represses trunk mesoderm and induces anterior endomesoderm in a cooperative manner with the pan-endodermal gene Mix.1. Furthermore, Xblimp1 can cooperate with the BMP inhibitor chordin to induce ectopic heads, while a dominant-negative Xblimp1 inhibits head formation. The head inducer cerberus is positively regulated by Xblimp1 and is able to rescue microcephalic embryos caused by dominant-negative Xblimp1. Our results indicate that Xblimp1 is required for anterior endomesodermal cell fate and head induction.
