INVESTIGADORES
D'ACCORSO Norma Beatriz
artículos
Título:
Synthesis and antiviral evaluation of some carbonucleoside analogues
Autor/es:
MARTINS ALHO MIRIAM A.; ERREA MARÍA I.; SGUERRA VANESA L.; D'ACCORSO NORMA B.; TALARICO LAURA; GARCÍA CYBELLE C.; DAMONTE ELSA B.
Revista:
JOURNAL OF HETEROCYCLIC CHEMISTRY
Editorial:
HeteroCorporation
Referencias:
Lugar: Tampa; Año: 2005 p. 979 - 983
ISSN:
0022-152X
Resumen:
1,2-O-Isopropylidene-alfa-L-threofuranosyl heterocyclic derivatives were synthesized from 1,2-O-isopropylidene-alfa-D-xilopentadialdo-1,4-furanose and tested for antiviral activity against herpes simplex virus type 1, dengue virus type 2 and Junin virus. For comparative propose, the antiviral activity of some of their pyranosyl analogues were also tested. The furanosyl derivatives showed to be moderate inhibitors of Junin virus and, in general, proved to be more effective than the pyranosyl analogues.
