Synthesis of novel carbohydrate acridinone derivatives using 1,3-dipolar cycloaddition with potential biological activities.

FASCIO MIRTA L.; DOCAMPO PALACIOS MAITE; PELLÓN ROLANDO F.; D'ACCORSO NORMA B.

SYNTHETIC COMMUNICATIONS

Taylor & Francis

Lugar: Nueva York Estados Unidos de América; Año: 2007 vol. 37 p. 4209 - 4217

0039-7911

Novel 10-f[3-(6-hydroxy-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)-4,5-dihydro-5-isoxazolyl]methyl-9(10H)-acridinone derivatives (13?16) were synthesized by 1,3-dipolar cycloaddition using the carbohydrate derivative as dipole and different 10-allyl-9(10H)-acridinone derivatives (9?12) as dipolarophiles. The new cycloadducts as well as the dipolarophiles precursors were characterized spectroscopically. Novel 10-f[3-(6-hydroxy-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)-4,5-dihydro-5-isoxazolyl]methylg-9(10H)-acridinone derivatives (13?16) were synthesized by 1,3-dipolar cycloaddition using the carbohydrate derivative as dipole and different 10-allyl-9(10H)-acridinone derivatives (9?12) as dipolarophiles. The new cycloadducts as well as the dipolarophiles precursors were characterized spectroscopically. Novel 10-f[3-(6-hydroxy-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)-4,5-dihydro-5-isoxazolyl]methylg-9(10H)-acridinone derivatives (13?16) were synthesized by 1,3-dipolar cycloaddition using the carbohydrate derivative as dipole and different 10-allyl-9(10H)-acridinone derivatives (9?12) as dipolarophiles. The new cycloadducts as well as the dipolarophiles precursors were characterized spectroscopically. Keywords: acridinones, carbohydrates, 1,3-dipolar cycloaddition, isoxazolines, N-allylation.acridinones, carbohydrates, 1,3-dipolar cycloaddition, isoxazolines, N-allylation.