Dexras 1 potentiates photic and suppresses non-photic responses of the circadian clock.

CHENG H.Y., OBRIETAN K., CAIN S.W., LEE B., AGOSTINO P.V., JOZA N., HARRINGTON M.E., RALPH M.R. AND PENNINGER J.M.

NEURON

Cell Press

Año: 2004 vol. 43 p. 715 - 728

0896-6273

Circadian rhythms of physiology and behavior are generated by biological clocks that are synchronized to the cyclic environment by photic or nonphotic cues. The interactions and integration of various entrainment pathways to the clock are poorly understood. Here, we show that the Ras-like G protein Dexras1 is a critical modulator of the responsiveness of the master clock to photic and nonphotic inputs. Genetic deletion of Dexras1 reduces photic entrainment by eliminating a pertussis-sensitive circadian response to NMDA. Mechanistically, Dexras1 couples NMDA and light input to Gi/o and ERK activation. In addition, the mutation greatly potentiates nonphotic responses to neuropeptide Y and unmasks a nonphotic response to arousal. Thus, Dexras1 modulates the responses of the master clock to photic and nonphotic stimuli in opposite directions. These results identify a signaling molecule that serves as a differential modulator of the gated photic and nonphotic input pathways to the circadian timekeeping system.