INVESTIGADORES
ORTEGA Hugo Hector
artículos
Título:
Altered expression of Transforming Growth Factor Beta isoforms in bovine cystic ovarian disease
Autor/es:
MATILLER, V; STANGAFERRO M; ORTEGA HH; DIAZ, PU; REY F; HUBER E; SALVETTI NR
Revista:
REPRODUCTION IN DOMESTIC ANIMALS (1990)
Editorial:
WILEY-BLACKWELL PUBLISHING, INC
Referencias:
Lugar: Londres; Año: 2014 vol. 49 p. 813 - 823
ISSN:
0936-6768
Resumen:
Cystic
ovarian disease (COD) is one of the main causes of infertility in dairy cattle.
It has been shown that intra-ovarian factors may contribute to follicular
persistence. Transforming growth factor-beta (TGFB) isoforms are important
paracrine and autocrine signalling molecules that regulate ovarian follicle
growth and physiology. Considering the importance of these factors in the
ovarian physiology, in this study, we examined the expression of TGFB isoforms
(TGFB1, TGFB2 and TGFB3) in the ovary of healthy cows and animals with spontaneous
and adrenocorticotrophic hormone (ACTH)-induced COD. In the
oestrous-synchronized control group, the expression of TGFB1 in granulosa and
theca cells was higher in spontaneous cysts than in atretic or tertiary
follicles. When we compared TGFB2 expression in granulosa cells from atretic or
tertiary follicles from the oestrous-synchronized control group with that in
ACTH-induced or spontaneous follicular cysts, we found a higher expression in
the latter. The expression of the TGFB isoforms studied was also altered during
folliculogenesis in both the spontaneous and ACTHinduced COD groups. As it has
been previously shown that TGFB influences steroidogenesis, ovarian follicular
proliferation and apoptosis, an alteration in its expression may contribute to
the pathogenesis of this disease.