Human chagasic IgG interacting with lymphocyte neurotransmitter receptors triggers signal transduction

STERIN-BORDA, L.; GORELIK ,G.; GENARO, A.; GOIN, J.C.; BORDA, E.S.

FASEB JOURNAL

Federation of American Societies for Experimental Biology

Lugar: Bethesda (MD), USA; Año: 1990 vol. 4 p. 1661 - 1667

0892-6638

It is demonstrated that human IgG in Chagas´ disease and the corresponding F(ab)´2 fragment attach to lymphoid cells by specific interaction with beta-adrenergic and muscarinic cholinergic receptors. This interaction resulted in the transduction of signals that increased intracellular levels of cAMP in enriched T helper cell preparations and cGMP in enriched T suppressor cell preparations. The stimulation of Ts cell muscarinic cholinergic receptors by Chagas IgG or the corresponding F(ab)´2 fraction triggers the release of the immunomodulatory substance PGE2. These results are unified in a theory of immunoregulation and could contribute to the chronic course of Chagas´ disease.