INVESTIGADORES
PALAZZOLO Martin Alejandro
artículos
Título:
Organocatalytic synthesis of novel purine and pyrimidine acyclic nucleosides
Autor/es:
PALAZZOLO, M. A.; PÉREZ-SÁNCHEZ, M.; IRIBARREN, A. M.; LEWKOWICZ, E. S.; DOMÍNGUEZ DE MARÍA, P.
Revista:
TETRAHEDRON LETTERS
Editorial:
PERGAMON-ELSEVIER SCIENCE LTD
Referencias:
Lugar: Amsterdam; Año: 2012 vol. 53 p. 6797 - 6800
ISSN:
0040-4039
Resumen:
Organocatalysis is assessed for the first time in the synthesis of purine and pyrimidine acyclic nucleosides providing high yields and straightforward work-up procedures. Nucleobases containing aldehydes are catalytically ligated (C?C bond formation) to acetone or to phosphonate-containing ketones by means of pyrrolidine or silica-immobilized piperazine as amine-based organocatalysts.
