INVESTIGADORES
BRUVERA Ignacio Javier
artículos
Título:
An integrated device for magnetically-driven drug release and in situ quantitative measurements: design, fabrication and testing
Autor/es:
I J BRUVERA; R. HERNÁNDEZ; C. MIJANGOS; GOYA R.G.
Revista:
JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS
Editorial:
ELSEVIER SCIENCE BV
Referencias:
Lugar: Amsterdam; Año: 2015 vol. 377 p. 446 - 451
ISSN:
0304-8853
Resumen:
We have developed a device capable of remote triggering and in situ quantification of therapeutic drugs,
based on magnetically-responsive hydrogels of poly (N-isopropylacrylamide) and alginate (PNiPAAm).
The heating efficiency of these hydrogels measured by their specific power absorption (SPA) values
showed that the values between 100 and 300 W/g of the material were high enough to reach the lower
critical solution temperature (LCST) of the polymeric matrix within few minutes. The drug release
through application of AC magnetic fields could be controlled by time-modulated field pulses in order to
deliver the desired amount of drug. Using B12 vitamin as a concept drug, the device was calibrated to
measure amounts of drug released as small as 25(2) 109 g, demonstrating the potential of this device
for very precise quantitative control of drug release.
