INVESTIGADORES
ALVAREZ IGARZABAL Cecilia Ines
artículos
Título:
Novel poly(NIPA-co-AAc) functional polymers for application in topical and oral drug delivery formulations
Autor/es:
CUGGINO JC; CONTRERAS C; A. JIMENEZ-KAIRUZ; ALVAREZ IGARZABAL C.I.
Revista:
MOLECULAR PHARMACEUTICS
Editorial:
AMER CHEMICAL SOC
Referencias:
Lugar: Washington; Año: 2014 vol. 11 p. 2239 - 2249
ISSN:
1543-8384
Resumen:
ABSTRACT: The synthesis, characterization and properties of
pH/thermosensitive hydrogels based on acrylic acid (AAc) and Nisopropylacrylamide
(NIPA) using (+)-N,N′-diallyltartramide
(DAT) as cross-linking agent and water as solvent, are presented
in this article. Subsequently, the incorporation of ofloxacin (OFL) as
model drug to evaluate the drug load capacity of hydrogels and the
in vitro release from OFL-polymer conjugate are presented in order
to define potential pharmaceutical applications. Interestingly, the
incorporation of AAc diversified the properties of NIPA-based
hydrogels allowing ionic interaction of these new materials with
drugs of opposite charge and produced different release profiles at
pH 1.2 and 6.8 simulated physiological media.