PERSONAL DE APOYO
LACUNZA Josefina
artículos
Título:
Cephalotin Penetration into Muscle Tissue Fluid and Muscle Tissue
Autor/es:
ROBERTO RULE; MARIANGELES VITA; JOSEFINA LACUNZA
Revista:
Latin American Journal of Pharmacy
Editorial:
Acta Farmacéutica Bonaerense
Referencias:
Año: 2008 vol. 27
ISSN:
2362-3853
Resumen:
SUMMARY. The aim ot fhe present work was to compare the penetration in muscle tissue fluid (MTF)and muscle tissue (MT) of cephalotin administered in rabbits. Animals were distributed in Trial 1 (n = 15)and Trial 2 ( n= 6). In the Trial 1 the animals were implanted in ischiotibial muscle with non reactive materialcages. Animals recibed subcutaneously (sc) cephalotin (20 mg/kg) and blood, MTF and MT sampleswere recollected. In the Trial 2 the animals recibed cephalotin (20 mg/kg) intravenously (iv) and bloodsamples were recollected. Pharmacokinetic analysis were performed using a non-compartmental model.Results: terminal disposition rate constant (λz) (serum iv) 1.43 ± 0.54, (serum sc) 1.90, (MTF) 0.57 and(MT) 1.80 h?1; elimination half-life (t1/2) (serum iv) 0.53 ± 0.13, (serum sc) 0.36, (MTF) 1.20 and (MT) 0.38h; the area under the curve [AUC(0-6)] (serum iv) 60.40 ± 38.20, (serum sc) 45.90, (MTF) 21.60 and (MT)3.00 μg.ml?1.h. and the bioavailability (F) was 76%. The penetration of cephalotin in MTF and MT were47.70 and 6.43%, respectively. Cephalotin administered subcutaneously in rabbit presented higherbioavailability, distribution in extracelullar fluid and low penetration in muscle tissue.