PERSONAL DE APOYO
CUELLO CARRION Fernando Dario
artículos
Título:
Impact of tumor necrosis factor receptor p55 deficiency in susceptibility of C57BL/6 mice to infection with Leishmania (Leishmania) amazonensis
Autor/es:
CARGNELUTTI D. E.; SALOMÓN M. C.; CELEDON V.; CUELLO CARRION F. D.; GEA S.; DI GENARO M. S.; SCODELLER E. A.
Revista:
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
Editorial:
SCIENTIFIC COMMUNICATIONS INT LTD
Referencias:
Lugar: Taiwan; Año: 2014
ISSN:
1684-1182
Resumen:
Tumor necrosis factor (TNF) is involved in host resistance to several intracellular pathogens. Although the critical role of TNF receptor (TNFR) p55 in Leishmania (Leishmania) major infection has been demonstrated, the impact of TNFRp55 deficiency on L. (L.) amazonensis infection has not been explored. L. (L.) amazonensis-infected TNFRp55-/- mice failed to resolve lesions, whereas C57BL/6 wild-type mice completely healed. The susceptibility of the TNFRp55-/- mice was characterized by higher lesion size and histopathological damage in comparison with the wild-type mice. A marked increased of the splenic index was observed.
