INVESTIGADORES
GENARO Ana Maria
artículos
Título:
Immune alterations induced by chronic noise exposure: comparison with restraint stress in BALB/c and C57Bl/6 mice.
Autor/es:
CECILA GABRIELA PASCUAN; SOLEDAD L. URÁN; MARÍA ROSA GONZALEZ MURANO; MIRIAM RUTH WALD; LAURA RUTH GUELMAN; ANA MARÍA GENARO
Revista:
JOURNAL OF IMMUNOTOXICOLOGY
Editorial:
INFORMA HEALTHCARE
Referencias:
Lugar: London; Año: 2014 vol. 11 p. 78 - 83
ISSN:
1547-691X
Resumen:
Exposure to loud noise levels represents a problem in all regions of the
world. Noise exposure is known to affect auditory structures in
living organisms. However, it should not be ignored that many of the
effects of noise are extra-auditory. In particular, it has been
proposed that noise could affect immune system similarly to other
stressors. Nevertheless, only a few studies so far have investigated
the effects of noise on the immune function. The aim of the present
work was to investigate the effect of chronic (2 weeks) noise
(95-97 dBA) exposure on immune responses in BALB/c and C57 mice. To
ascertain if the effect of noise is similar to other psychological
stressors, the effect of chronic restraint--applied for the same
time--on immune response was also analyzed. It was found that chronic
noise impaired immune-related end-points in vivo and ex vivo depending
on the strain used. Noise, but not restraint, affected C57Bl/6 mouse
T-cell-dependent antibody production and ex vivo stimulated T-cell
proliferation, but had no effect on these parameters in BALB/c mice or
their cells. In fact, none of the stressors altered T-cell responses
associated with the BALB/c mice. Further, noise exposure induced a
decrease in corticosterone and catecholamines levels in BALB/c mice.
In contrast, no differences were seen in these parameters for those
BALB/c mice under restraint or for that matter C57Bl/6 mice exposed to
restraint or noise. The results of these studies indicate that noise
could seriously affect immune responses in susceptible individuals. In
addition, it may also be concluded that noise possibility should not
be considered a classic stressor.