INVESTIGADORES
MARCIPAR Ivan Sergio
artículos
Título:
Decreased level of antibodies and cardiac involvement in patients with chronic Chagas heart disease vaccinated with BCG
Autor/es:
VICCO MIGUEL; BONTEMPI IVAN; RODELES LUZ; YODICE ALBERTO; MARCIPAR IVÁN; BOTASSO OSCAR
Revista:
MEDICAL MICROBIOLOGY AND IMMUNOLOGY
Editorial:
SPRINGER
Referencias:
Lugar: Berlin; Año: 2014 vol. 203 p. 133 - 139
ISSN:
0300-8584
Resumen:
Studies indicate that Trypanosoma cruzi is
capable of inducing immunological disturbances such as
decreased expression of molecules involved in T-cell survival and costimulation for antigen-driven T-cell responses. On the other hand, several reports have described that
BCG vaccination induces a T-helper 1-type immune
response with protective effects in different pathologies. In
this regard, we evaluated whether BCG vaccination coexists with a better clinical and immunological profile of
chronic Chagas heart disease (CCHD). We performed a
cross-sectional study inT. cruziseropositive patients categorized according the BCG vaccine background and to the
well-established CCHD classification provided by Storino
et al. All individuals were subjected to a complete clinical
examination. All patients presented detectable levels of
autoantibodies anti-p2b, anti-B13, anti-FRA and antiparasite homogenate immunoglobulins, which were unrelated
to age and sex distribution or blood pressure values.
Comparisons according to BCG vaccination revealed that
individuals who had not been vaccinated presented higher
values of antibodies, and patients without BCG vaccine had
an OR of 6.1 (95 % CI 1.23?29.25,p=0.02) for globally
dilated cardiomyopathy with reduced ejection fraction(Hosmer and Lemeshow test of 5.2p=0.73). Our results
suggest that BCG vaccination coexists with a better clinical
and immunological profile of CCHD, associated with lower
cardiac involvement.