IFIBYNE   05513
INSTITUTO DE FISIOLOGIA, BIOLOGIA MOLECULAR Y NEUROCIENCIAS
Unidad Ejecutora - UE
artículos
Título:
Galectin-1 suppresses autoimmune retinal disease by promoting concomitant Th2- and T regulatory-mediated anti-inflammatory responses
Autor/es:
TOSCANO MA, COMMODARO AG, ILARREGUI JM, BIANCO GA, LIBERMAN A, SERRA HM, HIRABAYASHI J, RIZZO LV, RABINOVICH GA
Revista:
JOURNAL OF IMMUNOLOGY
Referencias:
Año: 2006 p. 6323 - 6332
ISSN:
0022-1767
Resumen:
Intraocular inflammatory diseases are a common cause of severe visual
impairment and blindness. In this study, we investigated the
immunoregulatory role of galectin-1 (Gal-1), an endogenous lectin found
at sites of T cell activation and immune privilege, in experimental
autoimmune uveitis (EAU), a Th1-mediated model of retinal disease.
Treatment with rGal-1 either early or late during the course of
interphotoreceptor retinoid-binding protein-induced EAU was sufficient
to suppress ocular pathology, inhibit leukocyte infiltration, and
counteract pathogenic Th1 cells. Administration of rGal-1 at the early
or late phases of EAU ameliorated disease by skewing the uveitogenic
response toward nonpathogenic Th2 or T regulatory-mediated
anti-inflammatory responses. Consistently, adoptive transfer of CD4(+)
regulatory T cells obtained from rGal-1-treated mice prevented the
development of active EAU in syngeneic recipients. In addition,
increased levels of apoptosis were detected in lymph nodes from mice
treated with rGal-1 during the efferent phase of the disease. Our
results underscore the ability of Gal-1 to counteract Th1-mediated
responses through different, but potentially overlapping
anti-inflammatory mechanisms and suggest a possible therapeutic use of
this protein for the treatment of human uveitic diseases of autoimmune
etiology.