Nucleophilic non-metal assited trifluoromethylation and perfluoroalkylation reactions of organic substrates

BARATA VALLEJO, SEBASTIAN; TORVISIO M. ROSARIO; LANTAÑO BEATRIZ; BONESI, S. M.; POSTIGO J. ALBERTO

JOURNAL OF FLUORINE CHEMISTRY

ELSEVIER SCIENCE SA

Lugar: Amsterdam; Año: 2014 vol. 161 p. 134 - 141

0022-1139

Nucleophilic trifluoromethylation and perfluoroalkylation reactions have been the outstanding approach during the last few decades to effect fluoroalkyl group addition or substitution reactions. In most instances, perfluoroalkyl-metal species participate at the beginning of the reactions. In this account, however, the latest nucleophilic non-metal assisted or uncatalyzed trifluoromethylation and perfluoroalkylation reactions of substrates bearing biological relevance will be discussed.  2014 Elsevier B.V. All rights reserved.