CIVETAN   23983
CENTRO DE INVESTIGACION VETERINARIA DE TANDIL
Unidad Ejecutora - UE
artículos
Título:
Efficacy of a Single High Oxfendazole Dose Against Gastrointestinal Nematodes in Naturally Infected Pigs.
Autor/es:
ALVAREZ, L., SAUMELL, C., FUSÉ, L., MORENO, L., CEBALLOS, L., DOMINGUE, G., DONADEU, M., DUNGU, B., LANUSSE, C.
Revista:
VETERINARY PARASITOLOGY
Editorial:
ELSEVIER SCIENCE BV
Referencias:
Lugar: Amsterdam; Año: 2013 p. 70 - 74
ISSN:
0304-4017
Resumen:
The goal of the current experiment was to assess the clinical efficacy of oxfendazole (OFZ)
administered as a single oral dose (30 mg/kg) to pigs naturally parasitized with Ascaris
suum, Oesophagostomum spp., Metastrongylus spp. and Trichuris suis. Thirty-six local ecotype
piglets were divided into three independent experiments, named I, II and III (n = 12
each), respectively. Each experiment involved two different groups (n = 6): Untreated Control
and OFZ treated. Animals were naturally parasitized with A. suum (Experiments I, II
and III), Oesophagostomum spp. (Experiments I and II), T. suis (Experiments II and III) and
Metastrongylus spp. (Experiment I). Pigs in the treated group received OFZ (Synanthic®,
Merial Ltd., 9.06% suspension) orally at 30 mg/kg dose. At five (5) days post-treatment,
animals were sacrificed and the clinical efficacy of the OFZ treatment was established following
the currently available WAAVP guidelines for a controlled efficacy test. None of
the animals involved in this experiment showed any adverse events during the study.
OFZ treatment given as a single 30 mg/kg oral dose showed a 100% efficacy against all
the nematode parasites present in the three experiments. In conclusion, under the current
experimental conditions, OFZ orally administered to naturally parasitized piglets at a single
dose of 30 mg/kg was safe and highly efficacious (100%) against adult stages of A. suum,
Oesophagostomum spp., T. suis and Metastrongylus spp.