INVESTIGADORES
MARCIPAR Ivan Sergio
artículos
Título:
Cardiovascular risk factors in chronic Chagas´ disease are associated with a different profile of putative heart-pathogenic antibodies
Autor/es:
DIEZ, CRISTINA; GEA, SUSANA; MARCIPAR, IVAN; PEZZOTTO, STELLA; BELOSCAR, JUAN; PELLIZZON, OSCAR; MARCIPAR, ALBERTO; BOTTASSO, OSCAR.
Revista:
FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY
Referencias:
Año: 2006 vol. 48 p. 26 - 33
ISSN:
0928-8244
Resumen:
Given that cardiovascular risk factors (CRF), such as smoking, alcoholism and
hypertension, may contribute to the development of heart lesions, chronically
Trypanosoma cruzi-infected individuals were studied to explore the relationship
between the presence of such CRF, cardiomyopathy and antibodies that have been
proposed to play a pathogenetic role in Chagas disease. The targets of these
antibodies were T. cruzi antigens such as cruzipain (Cz), a P ribosomal antigen
(P2), and a component of myelin sheaths also present in T. cruzi (sulphatide).
Individuals were classified into four groups on the basis of specific serology and
presence of CRF: subjects with T. cruzi infection and CRF; those with positive
serology and no CRF; seronegatives with CRF; and seronegatives without CRF,
were analysed. Seronegatives or seropositives with CRF showed a greater occurrence
of heart involvement (chest X-ray and/or electrocardiogram abnormalities).
Seropositives with CRF displayed significantly higher levels of antisulphatide
antibodies than the three remaining groups and higher levels of antibodies against
Cz and P2 compared to the seropositives without CRF. Increased amounts of anti-
P2 and antisulphatide antibodies were also found in seropositives with marked
heart involvement. The presence of CRF is associated with a different profile of
antibody responses and degree of cardiac effects.