INVESTIGADORES
HOZBOR Daniela Flavia
artículos
Título:
Resurgence of pertussis calls for re-evaluation of pertussis animal models
Autor/es:
VAN DER ARK A; HOZBOR D; BOOG CJP; METZ B; VAN DEN DOBBLESTEEN; VAN ELS C
Revista:
EXPERT REVIEW OF VACCINES
Editorial:
EXPERT REVIEWS
Referencias:
Año: 2012 p. 1 - 17
ISSN:
1476-0584
Resumen:
Pertussis has recently re-emerged in well-vaccinated populations most
likely due to a combination of pathogen adaptation and waning of
vaccine-induced pertussis immunity. Changes in genomic content of the
etiologic agent, Bordetella pertussis, observed in the postvaccination
era can have a bearing on the efficacy of vaccines currently in use.
Moreover, protective immune responses in vaccinees wane gradually
depending on their originally induced size and breadth, and memory
responses may not be as regularly boosted by circulating strains as was
the case in the prevaccination era. This pertussis scenario asks for
new, improved vaccines with at least a longer duration of protection.
Pertussis vaccine research, development and postmarketing surveillance
require re-evaluation and innovation of the currently available
pertussis animal models, with emphasis on the use of circulating B.
pertussis strains.