INVESTIGADORES
ELGOYHEN Ana Belen
artículos
Título:
a9: an acetylcholine receptor with novel pharmacological properties expressed in rat cochlear hair cells
Autor/es:
ELGOYHEN AB; JOHNSON D; BOULTER J; VETTER D; HEINEMANN S
Revista:
CELL
Editorial:
CELL PRESS
Referencias:
Lugar: United States; Año: 1994 vol. 79 p. 705 - 715
ISSN:
0092-8674
Resumen:
We report the isolation and functional characterization
of a member of the nicotinic acetylcholine receptor
subunit gene family, cc9. Xenopus oocytes injected
with a9 cRNA express a homomeric receptor-channel
complex that is activated by acetylcholine. The a9 receptor
displays an unusual mixed nicotinic-muscarinic
pharmacological profile. The unique properties of
the a9 receptor-channel complex closely match those
described for the cholinergic receptor present in vertebrate
cochlear hair cells. In situ hybridization studies
reveal a restricted pattern of a9 gene expression that
includes the outer hair cells of the rat cochlea. Our
results suggest that the cc9 receptor is involved in the
cholinergic efferent innervation of cochlear hair cells
and thus may modulate the encoding of auditory stimuli.