INVESTIGADORES
BARBEITO Claudio Gustavo
artículos
Título:
An Argentine Equine Herpesvirus Strain with Special Restriction Patterns Protect Mice Challenged with a Pathogenic Strain
Autor/es:
GALOSSI CM; BARBEITO CG; MARTÍN OCAMPOS G; MARTÍNEZ JP; AYALA M; CORVA S; ECHEVERRIGARAY ME; GIMENO EJ
Revista:
JOURNAL OF VETERINARY MEDICINE B
Editorial:
Blackwell Verlang
Referencias:
Lugar: Berlín; Año: 2006 vol. 53 p. 412 - 417
Resumen:
Equine herpesvirus 1 (EHV-1) was .rst isolated in Argentina
in 1979. This strain SPv has especial restriction patterns, but
a previous study demonstrated that SPv did not modify its
growth in cell culture. In addition, it showed low virulence
in the mouse respiratory model consistently with results
found in female BALB/C at di.erent state of gestation. This
study evaluates in a mouse respiratory model, if primary
infection with SPv strain protects animals from subsequent
challenge with a pathogenic strain. Body weight loss was not
observed in mice intranasally inoculated with SPv strain and
challenged with HH1 Japanese strain. The SPv primary
infection does not completely prevent clinical presentation
by HH1 infection but the SPv inoculated animals recovered
more quickly, with less intense and less persistent histological
lesions. The challenge infection caused a rapid and
prolonged increase in anti-EHV-1 antibodies in the mice
previously infected with SPv, along with a more rapid
reduction of viral titres in lungs. In this work it was demonstrated
that this EHV-1 strain constitute a good immunogen.
These results show that this SPv strain could be
considered to produce an EHV-1 vaccine.