INVESTIGADORES
BERNABEU Ramon Oscar
artículos
Título:
Hippocampal cGMP and cAMP are deferentially involved in memory processing of an inhibitory avoidance learning.
Autor/es:
BERNABEU, R., SCHMITZ, P., FAILLACE, M.P., IZQUIERDO, I. & MEDINA, J.
Revista:
NEUROREPORT
Editorial:
LIPPINCOTT WILLIAMS & WILKINS
Referencias:
Lugar: Philadelphia; Año: 1996 vol. 7 p. 585 - 588
ISSN:
0959-4965
Resumen:
Cyclic GMP (cGMP) and cyclic AMP (cAMP) have been proposed to
participate in the early and late stages of long-term potentiation
(LTP), respectively. Here we report on the effect of post-training
intrahippocampal infusion of membrane-permeable analogues of these
cyclic nucleotides on the consolidation of inhibitory avoidance learning
in rats and on the effect of this task on hippocampal cGMP and cAMP
levels. Bilateral intrahippocampal microinjection of 8 Br-cGMP (1.25
[mu]g per side) enhanced retention test performance when given
immediately (0 min), but not when given 180 min, after training. In
marked contrast, intrahippocampal infusion of the same dose of 8 Br-cAMP
facilitated memory consolidation when given 180 min, but not 0 min,
after training. Rats submitted to an inhibitory avoidance task showed a
significant increase in the amount of cGMP in the hippocampus at 0 and
30 min after training, and in the amount of cAMP 30 and 180 min after
training. Taken together, these results indicate that cGMP-regulated
processes in the hippocampus play an important role in the early stages
of memory consolidation and that cAMP signalling pathways are involved
in the late post-training memory processing of inhibitory avoidance
learning.