Synthesis of S-and C-galactofuranosides via a galactofuranosyl iodide. Isolable 1-galactofuranosylthiol as a new glycosyl donor.

LUCIANA BALDONI; CARLA MARINO

CARBOHYDRATE RESEARCH

ELSEVIER SCI LTD

Año: 2012

0008-6215

The use of the easily available persilylated derivative 1 for the synthesis of C- and S-Galf derivatives has been investigated. By anomeric iodination of 1 with TMSI, followed by in situ coupling with C- and S-nucleophiles under very mild conditions and in the absence of promoters, derivatives with value as glycomimetics or as precursors of glycobiological tools were synthesized. Among them, the synthesis of the isolable 1-galactofuranosylthiol 15 is remarkable, as it paves the way for alternative approaches for S-galactofuranosyl derivatives.