INVESTIGADORES
PALERMO Jorge Alejandro
artículos
Título:
New Cytotoxic Cucurbitacins from Wilbrandia ebracteata Cogn.
Autor/es:
LANG, K.; GUIMARAES, T.; ROCHA MACHADO, V.; ZIMMERMANN, L.; SILVA, I.; TEIXEIRA, M.; DURAN, F.; PALERMO, J.; SIMOES, C.; CARO, M.; SCHENKEL, E.P.
Revista:
PLANTA MEDICA
Editorial:
GEORG THIEME VERLAG KG
Referencias:
Lugar: Stuttgart; Año: 2011 vol. 77 p. 1648 - 1651
ISSN:
0032-0943
Resumen:
Chemical investigation of the roots of Wilbrandia ebracteata
Cogn. (Cucurbitaceae) led to the isolation of two new (12) and
four known (36) cucurbitacins. Their structures were elucidated
by NMR and MS and compared with related compounds. The in
vitro cytotoxicity of isolated compounds was evaluated against
RD, KB, HCT-8, and A549 cell lines showing strong activity.