CIPYP 05508
CENTRO DE INVESTIGACIONES SOBRE PORFIRINAS Y PORFIRIAS
Unidad Ejecutora - UE
artículos
Título:
Combined Chemotherapy and ALA based Photodynamic Therapy in leukemic murine cells
Autor/es:
DIEZ B,; CORDO RUSSO R,; TEIJO MJ,; HAJOS S,; BATTLE A, ; FUKUDA H
Revista:
LEUKEMIA RESEARCH
Editorial:
PERGAMON-ELSEVIER SCIENCE LTD
Referencias:
Lugar: Amsterdam; Año: 2012 vol. 36 p. 1179 - 1184
ISSN:
0145-2126
Resumen:
A b s t r a c tThe effects of combined administration of doxorubicin (DOX) and vincristine (VCR), with 5-aminolevulinic acid photodynamic treatment (ALA-PDT), were analyzed in sensitive murine leukemic cell lines (LBR-) and DOX and VCR chemoresistant LBR-D160 and LBR-V160 cell lines. Low doses of DOX and VCR increased anti-cancer effect of ALA-PDT in LBR-cells. Decrease in cell survival was higher when the combination VCR + ALA-PDT was used compared to DOX + ALA-PDT. Resistant cell lines LBR-D160 andLBR-V160 were sensitive to ALA-PDT; however, no changes occured when combining therapies. Thus, ALA-PDT can overcome drug resistance and is a good candidate for using treating multidrug resistant (MDR) cells.
