CEFYBO   02669
CENTRO DE ESTUDIOS FARMACOLOGICOS Y BOTANICOS
Unidad Ejecutora - UE
artículos
Título:
Alterations of locomotor activity rhythm and sleep parameters in patients with advanced glaucoma.
Autor/es:
LANZANI, MF; DE ZAVALÍA NURIA; FONTANA HÉCTOR; SARMIENTO MI; GOLOMBEK D; ROSENSTEIN R.E.
Revista:
CHRONOBIOLOGY INTERNATIONAL
Editorial:
TAYLOR & FRANCIS INC
Referencias:
Lugar: Londres; Año: 2012 vol. 29 p. 911 - 919
ISSN:
0742-0528
Resumen:
Chronobiol Int. 2012 Aug;29(7):911-9. doi: 10.3109/07420528.2012.691146.
Alterations of locomotor activity rhythm and sleep parameters in patients with advanced glaucoma.
Lanzani MF, de Zavalía N, Fontana H, Sarmiento MI, Golombek D, Rosenstein RE.
Source
Laboratory
of Retinal Neurochemistry and Experimental Ophthalmology, Department of
Human Biochemistry, School of Medicine, University of Buenos
Aires/CEFyBO, CONICET, Buenos Aires, Argentina.
Abstract
The
aim of this study was to evaluate the effect of advanced glaucoma on
locomotor activity rhythms and related sleep parameters. Nine normal
subjects and nine age-matched patients with bilateral advanced primary
open-angle glaucoma, >10 yrs since diagnosis, were included in this
observational, prospective, case-control study. Patients were required
to record the timing and duration of their sleep and daily activities,
and wore an actigraph on the wrist of the nondominant arm for 20 d.
Activity rhythm period, MESOR (24-h time-series mean), amplitude
(one-half peak-to-trough variation), and acrophase (peak time), plus
long sleep episodes during the wake state, sleep duration, efficiency,
and latency, as well as mean activity score, wake minutes, and mean wake
episodes during the sleep interval were assessed in controls and
glaucomatous patients. Glaucomatous patients exhibited significant
decrease in nighttime sleep efficiency, and significant increase in the
mean activity score, wake minutes, and mean wake episode during the
night. These results suggest that alterations of circadian physiology
could be a risk to the quality of life of patients with glaucoma.