CIVETAN   23983
CENTRO DE INVESTIGACION VETERINARIA DE TANDIL
Unidad Ejecutora - UE
artículos
Título:
Nematodicidal activity of flubendazole and its reduced metabolite on a murine model of Trichinella spiralis Infection.
Autor/es:
URBIZU, L; CONFALONIERI, A; SANCHEZ BRUNI S; LANUSSE, C; ALVAREZ, I
Revista:
CHEMOTHERAPY
Editorial:
KARGER
Referencias:
Lugar: Basel; Año: 2012 vol. 58 p. 295 - 298
ISSN:
0009-3157
Resumen:
Background: Flubendazole (FLBZ) is a broad-spectrum
benzimidazole anthelmintic compound. The parent FLBZ
is metabolized to its reduced (R-FLBZ) and hydrolyzed (HFLBZ)
metabolites. There are no data on the potential nematicidal
activity of R-FLBZ, the main plasma metabolite found
in sheep and mice. The goal of the current work was to assess
the efficacy of FLBZ and R-FLBZ against Trichinella spiralis in
a mouse model. Methods: Both compounds were administered
to Balb/c mice infected with T. spiralis as either a cyclodextrin
aqueous solution or as a carboxymethylcellulose
suspension. Treatments were performed orally (5 mg/kg) at
1 day after infection with T. spiralis . The efficacy of the treatments
was assessed at day 6 after infection. Results: While
the efficacy obtained for FLBZ and R-FLBZ administered as a
solution was 94 and 98%, respectively, the efficacies obtained
after the treatment with FLBZ suspensions were 38%
(FLBZ) and 64% (R-FLBZ). Conclusion: Under the current experimental
conditions, a high nematicidal efficacy of both
FLBZ and R-FLBZ administered as solution preparations was
observed. Copyright © 2012 S. Karger AG, BaselFlubendazole (FLBZ) is a broad-spectrum
benzimidazole anthelmintic compound. The parent FLBZ
is metabolized to its reduced (R-FLBZ) and hydrolyzed (HFLBZ)
metabolites. There are no data on the potential nematicidal
activity of R-FLBZ, the main plasma metabolite found
in sheep and mice. The goal of the current work was to assess
the efficacy of FLBZ and R-FLBZ against Trichinella spiralis in
a mouse model. Methods: Both compounds were administered
to Balb/c mice infected with T. spiralis as either a cyclodextrin
aqueous solution or as a carboxymethylcellulose
suspension. Treatments were performed orally (5 mg/kg) at
1 day after infection with T. spiralis . The efficacy of the treatments
was assessed at day 6 after infection. Results: While
the efficacy obtained for FLBZ and R-FLBZ administered as a
solution was 94 and 98%, respectively, the efficacies obtained
after the treatment with FLBZ suspensions were 38%
(FLBZ) and 64% (R-FLBZ). Conclusion: Under the current experimental
conditions, a high nematicidal efficacy of both
FLBZ and R-FLBZ administered as solution preparations was
observed. Copyright © 2012 S. Karger AG, BaselTrichinella spiralis in
a mouse model. Methods: Both compounds were administered
to Balb/c mice infected with T. spiralis as either a cyclodextrin
aqueous solution or as a carboxymethylcellulose
suspension. Treatments were performed orally (5 mg/kg) at
1 day after infection with T. spiralis . The efficacy of the treatments
was assessed at day 6 after infection. Results: While
the efficacy obtained for FLBZ and R-FLBZ administered as a
solution was 94 and 98%, respectively, the efficacies obtained
after the treatment with FLBZ suspensions were 38%
(FLBZ) and 64% (R-FLBZ). Conclusion: Under the current experimental
conditions, a high nematicidal efficacy of both
FLBZ and R-FLBZ administered as solution preparations was
observed. Copyright © 2012 S. Karger AG, BaselMethods: Both compounds were administered
to Balb/c mice infected with T. spiralis as either a cyclodextrin
aqueous solution or as a carboxymethylcellulose
suspension. Treatments were performed orally (5 mg/kg) at
1 day after infection with T. spiralis . The efficacy of the treatments
was assessed at day 6 after infection. Results: While
the efficacy obtained for FLBZ and R-FLBZ administered as a
solution was 94 and 98%, respectively, the efficacies obtained
after the treatment with FLBZ suspensions were 38%
(FLBZ) and 64% (R-FLBZ). Conclusion: Under the current experimental
conditions, a high nematicidal efficacy of both
FLBZ and R-FLBZ administered as solution preparations was
observed. Copyright © 2012 S. Karger AG, BaselT. spiralis as either a cyclodextrin
aqueous solution or as a carboxymethylcellulose
suspension. Treatments were performed orally (5 mg/kg) at
1 day after infection with T. spiralis . The efficacy of the treatments
was assessed at day 6 after infection. Results: While
the efficacy obtained for FLBZ and R-FLBZ administered as a
solution was 94 and 98%, respectively, the efficacies obtained
after the treatment with FLBZ suspensions were 38%
(FLBZ) and 64% (R-FLBZ). Conclusion: Under the current experimental
conditions, a high nematicidal efficacy of both
FLBZ and R-FLBZ administered as solution preparations was
observed. Copyright © 2012 S. Karger AG, BaselT. spiralis . The efficacy of the treatments
was assessed at day 6 after infection. Results: While
the efficacy obtained for FLBZ and R-FLBZ administered as a
solution was 94 and 98%, respectively, the efficacies obtained
after the treatment with FLBZ suspensions were 38%
(FLBZ) and 64% (R-FLBZ). Conclusion: Under the current experimental
conditions, a high nematicidal efficacy of both
FLBZ and R-FLBZ administered as solution preparations was
observed. Copyright © 2012 S. Karger AG, BaselResults: While
the efficacy obtained for FLBZ and R-FLBZ administered as a
solution was 94 and 98%, respectively, the efficacies obtained
after the treatment with FLBZ suspensions were 38%
(FLBZ) and 64% (R-FLBZ). Conclusion: Under the current experimental
conditions, a high nematicidal efficacy of both
FLBZ and R-FLBZ administered as solution preparations was
observed. Copyright © 2012 S. Karger AG, BaselConclusion: Under the current experimental
conditions, a high nematicidal efficacy of both
FLBZ and R-FLBZ administered as solution preparations was
observed. Copyright © 2012 S. Karger AG, BaselCopyright © 2012 S. Karger AG, Basel