Photoproducts and proposed degradation pathway in the Riboflavin-sensitised photooxidation of Isoproterenol

WALTER A. MASSAD; JUAN M. MARIOLI; NORMAN A. GARCÍA

PHARMAZIE

Año: 2006 vol. 61 p. 1019 - 1021

0031-7144

Products of the aerobic visible-light-promoted riboflavin-sensitised photooxidation of the sympathomimetic drug Isoproterenol were identified by means of HPLC and spectrophotometric techniques. The oxidative process, mediated by superoxide radical anion, generates N-isopropylaminochrome as a main photoproduct with a quantum yield of 0.15. In parallel, the photodecomposition of riboflavin is prevented in the presence of isoproterenol. A reaction scheme for the photooxidation pathway of isoproterenol is proposed in analogy to former reports for related compounds.