Effects of Solanum glaucophyllum toxicity on cell proliferation and apoptosis in the small and large intestine of rabbits

ZANUZZI CN; NISHIDA F; PORTIANSKY EL; GIMENO EJ; BARBEITO CG

RESEARCH IN VETERINARY SCIENCE

ELSEVIER SCI LTD

Año: 2012 vol. 93 p. 336 - 342

0034-5288

Vitamin D regulates mineral homeostasis and enterocyte proliferation and differentiation.Hypervitaminosis D generates changes in cell proliferation, differentiation and apoptosis in severalorgans. We analyzed morphometric parameters and proliferative and apoptotic indices in theintestinal epithelium of rabbits with hypervitaminosis D induced by the chronic treatment with thecalcinogenic plant Solanum glaucophyllum. Rabbits were treated for 15 or 30 days. A group wastreated for 15 days and led to possible recovery for 30 days. Another group was nutritionally restrictedfor 30 days. Morphological, morphometric, proliferative and apoptotic changes were found in thetreated animals. Mild atrophy and reduced proliferation was found in the jejunum and ileum.Apoptosis increased in the crypts of the ileum and in the superficial epithelium and crypts of therectum. Most of the alterations were partially recovered. The possible involvement in these changes ofthe hypervitaminosis D-like state induced by S. glaucophyllum is discussed.