CEFYBO   02669
CENTRO DE ESTUDIOS FARMACOLOGICOS Y BOTANICOS
Unidad Ejecutora - UE
artículos
Título:
Toll-like receptor 4 plays a crucial role in the immuneadrenal response to systemic inflammatory response syndrome
Autor/es:
PAULA A. ZACHAROWSKI; ALEXANDER KOCH,; AIDA BABAN; NGUYEN TRAN; REINHARD BERKELS; CLAUDIA PAPEWALIS; KLAUS SCHULZE-OSTHOFF; PASCAL KNUEFERMANN; ULRICH ZAHRINGER; RALF R. SCHUMANN; VALERIA BESUHLI DE RETTORI; SAMUEL M. MCCANN; STEFAN R. BORNSTEIN
Revista:
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Referencias:
Año: 2006 vol. 103 p. 6392 - 6397
ISSN:
0027-8424
Resumen:
Sepsis and septic shock are leading killers in the noncoronary
intensive care unit, and they remain worldwide health concerns.
The initial host defense against bacterial infections involves Tolllike
receptors (TLRs), which detect and respond to microbial ligands.
In addition, a coordinated response of the adrenal and
immune systems is crucial for survival during severe inflammation.
Previously, we demonstrated a link between the innate immune
system and the endocrine stress response involving TLR-2. Like
TLR-2, TLR-4 is also expressed in human and mouse adrenals. In the
present work, by using a low dose of LPS to mimic systemic
inflammatory response syndrome, we have revealed marked cellular
alterations in adrenocortical tissue and an impaired adrenal
corticosterone response in TLR-4/ mice. Our findings demonstrate
that TLR-4 is a key mediator in the crosstalks between the
innate immune system and the endocrine stress response. Furthermore,
TLR polymorphisms could contribute to the underlying
mechanisms of impaired adrenal stress response in patients with
bacterial sepsis.
bacterial sepsis./ mice. Our findings demonstrate
that TLR-4 is a key mediator in the crosstalks between the
innate immune system and the endocrine stress response. Furthermore,
TLR polymorphisms could contribute to the underlying
mechanisms of impaired adrenal stress response in patients with
bacterial sepsis.
bacterial sepsis.