INVESTIGADORES
BERGADÁ Ignacio
artículos
Título:
Differentiated thyroid carcinoma: presentation and follow-up in children and
Autor/es:
PAPENDIECK P; GRUÑEIRO-PAPENDIECK L; VENARA M; ACHA O; MAGLIO S; BERGADÁ I; CHIESA A
Revista:
JOURNAL OF PEDIATRIC ENDOCRINOLOGY AND METABOLISM
Editorial:
Walter de Gruyter
Referencias:
Año: 2011 vol. 24 p. 743 - 748
ISSN:
2191-0251
Resumen:
To review our Pediatric Endocrinology Division ? s experience
with differentiated thyroid carcinoma (DTC) we analyzed retrospectively
the records of patients with DTC that had been
seen between June 1988 and June 2008.
Results: Forty-fi ve patients (median age 13.7 years, 36
female) were diagnosed (papillary: 40, follicular: 5) with DTC
presenting as a solitary nodule (n: 25), thyroid nodule with
cervical adenopathy (n: 9) and multinodular goiter (n: 11). All
underwent total thyroidectomy with resection of suspicious
cervical lymph nodes (CLN). DTC was multicentric in 59 %
and revealed extrathyroidal extension in 44 % . Initially, 44 %
had CLN metastases and 24 % distant metastases. All patients
underwent thyroid remnant ablation with 131 I and suppressive
treatment. Median follow-up was 5.1 years with a diseasefree
survival rate at 5 years of follow-up of 75 % . Eleven
percent presented recurrences.
treatment. Median follow-up was 5.1 years with a diseasefree
survival rate at 5 years of follow-up of 75 % . Eleven
percent presented recurrences.
female) were diagnosed (papillary: 40, follicular: 5) with DTC
presenting as a solitary nodule (n: 25), thyroid nodule with
cervical adenopathy (n: 9) and multinodular goiter (n: 11). All
underwent total thyroidectomy with resection of suspicious
cervical lymph nodes (CLN). DTC was multicentric in 59 %
and revealed extrathyroidal extension in 44 % . Initially, 44 %
had CLN metastases and 24 % distant metastases. All patients
underwent thyroid remnant ablation with 131 I and suppressive
treatment. Median follow-up was 5.1 years with a diseasefree
survival rate at 5 years of follow-up of 75 % . Eleven
percent presented recurrences.
treatment. Median follow-up was 5.1 years with a diseasefree
survival rate at 5 years of follow-up of 75 % . Eleven
percent presented recurrences.
Forty-fi ve patients (median age 13.7 years, 36
female) were diagnosed (papillary: 40, follicular: 5) with DTC
presenting as a solitary nodule (n: 25), thyroid nodule with
cervical adenopathy (n: 9) and multinodular goiter (n: 11). All
underwent total thyroidectomy with resection of suspicious
cervical lymph nodes (CLN). DTC was multicentric in 59 %
and revealed extrathyroidal extension in 44 % . Initially, 44 %
had CLN metastases and 24 % distant metastases. All patients
underwent thyroid remnant ablation with 131 I and suppressive
treatment. Median follow-up was 5.1 years with a diseasefree
survival rate at 5 years of follow-up of 75 % . Eleven
percent presented recurrences.
treatment. Median follow-up was 5.1 years with a diseasefree
survival rate at 5 years of follow-up of 75 % . Eleven
percent presented recurrences.
131 I and suppressive
treatment. Median follow-up was 5.1 years with a diseasefree
survival rate at 5 years of follow-up of 75 % . Eleven
percent presented recurrences.
Conclusion: Pediatric DTC has an aggressive behavior at
presentation. Higher preoperative TSH levels were signifi -
cantly associated with a more advanced disease at diagnosis.
CLT was present concomitantly in a quarter of the patients
and further studies are needed to establish differences in these
patients ? outcome. Diagnostic approach, total thyroidectomy,
presentation. Higher preoperative TSH levels were signifi -
cantly associated with a more advanced disease at diagnosis.
CLT was present concomitantly in a quarter of the patients
and further studies are needed to establish differences in these
patients ? outcome. Diagnostic approach, total thyroidectomy,
Pediatric DTC has an aggressive behavior at
presentation. Higher preoperative TSH levels were signifi -
cantly associated with a more advanced disease at diagnosis.
CLT was present concomitantly in a quarter of the patients
and further studies are needed to establish differences in these
patients ? outcome. Diagnostic approach, total thyroidectomy,
131 I treatment and thyrotropin suppression allowed a good
progression-free survival rate.
progression-free survival rate.
I treatment and thyrotropin suppression allowed a good
progression-free survival rate.