INVESTIGADORES
BOCCIA Mariano Martin
artículos
Título:
The type 5 phosphodiesterase inhibition for the treatment of eréctil dysfunction.
Autor/es:
BARATTI CM; BOCCIA MM; BLAKE MG; ACOSTA GB
Revista:
Revista Farmaceutica Review
Referencias:
Lugar: Buenos Aires - Argentina; Año: 2006 vol. 148 p. 34 - 44
ISSN:
0034-9496
Resumen:
The cyclic nucleotide second messenger cGMP generated by activate soluble guanylyl cyclase (sGC) in penile smooth muscle cells regulates penile erection by decreasing contractile tone. Activation of sGC requires nitric oxide (NO) released in the penis upon sexual stimulation from neural and endothelial sources containing NO synthase (NOS), respectively termed nNOS y eNOS. The cGMPC is catabolyzed by phosphodiesterases type 5ª (PDE5A) using the PDE5 inhibitors sildenafil, vardenafil y tadalafil, has proven quite successful as a clinical pharmacotherapeutic approach to treat erectil dysfunction.
