Modulation of Horizontally Acquired Genes by the Hha-YdgT Proteins in Salmonella enterica Serovar Typhimurium

AITZIBER VIVERO; ROSA C. BAÑOS; JAVIER FERNANDO MARISCOTTI; JUAN CARLOS OLIVEROS; FRANCISCO GARCÍA-DEL PORTILLO; ANTONIO JUÁREZ; CRISTINA MADRID

JOURNAL OF BACTERIOLOGY

AMER SOC MICROBIOLOGY

Lugar: Washington; Año: 2008 vol. 190 p. 1152 - 1156

0021-9193

We describe a transcriptomic study of the effect of hha and ydgT mutations in Salmonella enterica serovar Typhimurium. A large number of genes showing altered expression are located in AT-rich horizontally acquired DNA sequences. Many of these genes have also been reported to be targets for H-NS. As Hha and YdgT interact with H-NS, our findings strongly suggest that Hha and/or YdgT must form complexes with H-NS when they silence these DNA regions.