INVESTIGADORES
ISERTE Javier Alonso
artículos
Título:
Viral Diversity of Junín Virus field strains
Autor/es:
SANDRA E. GOÑI; BETINA I. STEPHAN; JAVIER A. ISERTE; MARTA S. CONTIGIANI; MARIO E. LOZANO; ANTONIO TENORIO
Revista:
VIRUS RESEARCH
Editorial:
ELSEVIER SCIENCE BV
Referencias:
Lugar: Amsterdam; Año: 2011 vol. 160 p. 150 - 158
ISSN:
0168-1702
Resumen:
The Argentine Hemorrhagic Fever, an endemic disease present in a much of
Argentina, is caused by the Junín virus (JUNV). Currently, there are
sequences available from several strains of this virus, like those
belonging to the vaccine lineage (XJ13, XJ#44 and Candid#1), as well as
MC2 (rodent isolate) and IV4454 (human isolate). In this article, we
report sequence information on two fragments of genomic segment S of
viral isolates from the endemic area. A Nested-RT-PCR was used to
amplify discrete genomic regions of 13 isolates of rodent and human
origin. The bioinformatics studies revealed a great homogeneity of
sequences among the JUNV isolates. The phylogenetic classification
showed greater evolutionary distance between the old world arenaviruses
(Lassa and LCM virus) than between the new world arenaviruses (JUNV and
Machupo virus).
