INSIBIO   05451
INSTITUTO SUPERIOR DE INVESTIGACIONES BIOLOGICAS
Unidad Ejecutora - UE
artículos
Título:
Role of phospholipase A2 pathway in regulating activation of
Autor/es:
M.T. AJMAT2, F. BONILLA2, P.C. HERMOSILLA3, L. ZELARAYÁN2 AND BÜHLER MI
Revista:
ZYGOTE
Editorial:
CAMBRIDGE UNIV PRESS
Referencias:
Lugar: Cambridge; Año: 2012 vol. 20 p. 1 - 7
ISSN:
0967-1994
Resumen:
Transient increases in the concentration of cytosolic Ca2+ are essential for triggering egg activation
events. Increased Ca2+ results from its rapid release from intracellular stores, mainly mediated by one
or both intracellular calcium channels: the inositol trisphosphate receptor (IP3R) and the ryanodine
receptor (RyR). Several regulatory pathways that tailor the response of these channels to the specific
cell type have been proposed. Among its many modulatory actions, calcium can serve as an activator
of a cytosolic phospholipase A2 (cPLA2), which releases arachidonic acid from phospholipids of the
endoplasmic reticulum as well as from the nuclear envelope. Previous studies have suggested that
arachidonic acid and/or its metabolites were able to modulate the activity of several ion channels.
Based on these findings, we have studied the participation of the phospholipase A2 (PLA2) pathway
in the process of Bufo arenarum oocyte activation and the interrelation between any of its metabolites
and the ion channels involved in the calcium release from the intracellular reservoirs at fertilization.
We found that addition of both melittin, a potent PLA2 activator, and arachidonic acid, the main
PLA2 reaction metabolite, was able to induce activation events in a bell-shaped manner. Differential
regulation of IP3Rs and RyRs by arachidonic acid and its products could explainmelittin and arachidonic
acid behaviour in Bufo arenarum egg activation. The concerted action of arachidonic acid and/or its
metabolites could provide controlled mobilization of calcium from intracellular reservoirs and useful
tools for understanding calcium homeostasis in eggs that express both types of receptors.
metabolites could provide controlled mobilization of calcium from intracellular reservoirs and useful
tools for understanding calcium homeostasis in eggs that express both types of receptors.
acid behaviour in Bufo arenarum egg activation. The concerted action of arachidonic acid and/or its
metabolites could provide controlled mobilization of calcium from intracellular reservoirs and useful
tools for understanding calcium homeostasis in eggs that express both types of receptors.
metabolites could provide controlled mobilization of calcium from intracellular reservoirs and useful
tools for understanding calcium homeostasis in eggs that express both types of receptors.
regulation of IP3Rs and RyRs by arachidonic acid and its products could explainmelittin and arachidonic
acid behaviour in Bufo arenarum egg activation. The concerted action of arachidonic acid and/or its
metabolites could provide controlled mobilization of calcium from intracellular reservoirs and useful
tools for understanding calcium homeostasis in eggs that express both types of receptors.
metabolites could provide controlled mobilization of calcium from intracellular reservoirs and useful
tools for understanding calcium homeostasis in eggs that express both types of receptors.
acid behaviour in Bufo arenarum egg activation. The concerted action of arachidonic acid and/or its
metabolites could provide controlled mobilization of calcium from intracellular reservoirs and useful
tools for understanding calcium homeostasis in eggs that express both types of receptors.
metabolites could provide controlled mobilization of calcium from intracellular reservoirs and useful
tools for understanding calcium homeostasis in eggs that express both types of receptors.
PLA2 reaction metabolite, was able to induce activation events in a bell-shaped manner. Differential
regulation of IP3Rs and RyRs by arachidonic acid and its products could explainmelittin and arachidonic
acid behaviour in Bufo arenarum egg activation. The concerted action of arachidonic acid and/or its
metabolites could provide controlled mobilization of calcium from intracellular reservoirs and useful
tools for understanding calcium homeostasis in eggs that express both types of receptors.
metabolites could provide controlled mobilization of calcium from intracellular reservoirs and useful
tools for understanding calcium homeostasis in eggs that express both types of receptors.
acid behaviour in Bufo arenarum egg activation. The concerted action of arachidonic acid and/or its
metabolites could provide controlled mobilization of calcium from intracellular reservoirs and useful
tools for understanding calcium homeostasis in eggs that express both types of receptors.
metabolites could provide controlled mobilization of calcium from intracellular reservoirs and useful
tools for understanding calcium homeostasis in eggs that express both types of receptors.
regulation of IP3Rs and RyRs by arachidonic acid and its products could explainmelittin and arachidonic
acid behaviour in Bufo arenarum egg activation. The concerted action of arachidonic acid and/or its
metabolites could provide controlled mobilization of calcium from intracellular reservoirs and useful
tools for understanding calcium homeostasis in eggs that express both types of receptors.
metabolites could provide controlled mobilization of calcium from intracellular reservoirs and useful
tools for understanding calcium homeostasis in eggs that express both types of receptors.
acid behaviour in Bufo arenarum egg activation. The concerted action of arachidonic acid and/or its
metabolites could provide controlled mobilization of calcium from intracellular reservoirs and useful
tools for understanding calcium homeostasis in eggs that express both types of receptors.
metabolites could provide controlled mobilization of calcium from intracellular reservoirs and useful
tools for understanding calcium homeostasis in eggs that express both types of receptors.
and the ion channels involved in the calcium release from the intracellular reservoirs at fertilization.
We found that addition of both melittin, a potent PLA2 activator, and arachidonic acid, the main
PLA2 reaction metabolite, was able to induce activation events in a bell-shaped manner. Differential
regulation of IP3Rs and RyRs by arachidonic acid and its products could explainmelittin and arachidonic
acid behaviour in Bufo arenarum egg activation. The concerted action of arachidonic acid and/or its
metabolites could provide controlled mobilization of calcium from intracellular reservoirs and useful
tools for understanding calcium homeostasis in eggs that express both types of receptors.
metabolites could provide controlled mobilization of calcium from intracellular reservoirs and useful
tools for understanding calcium homeostasis in eggs that express both types of receptors.
acid behaviour in Bufo arenarum egg activation. The concerted action of arachidonic acid and/or its
metabolites could provide controlled mobilization of calcium from intracellular reservoirs and useful
tools for understanding calcium homeostasis in eggs that express both types of receptors.
metabolites could provide controlled mobilization of calcium from intracellular reservoirs and useful
tools for understanding calcium homeostasis in eggs that express both types of receptors.
regulation of IP3Rs and RyRs by arachidonic acid and its products could explainmelittin and arachidonic
acid behaviour in Bufo arenarum egg activation. The concerted action of arachidonic acid and/or its
metabolites could provide controlled mobilization of calcium from intracellular reservoirs and useful
tools for understanding calcium homeostasis in eggs that express both types of receptors.
metabolites could provide controlled mobilization of calcium from intracellular reservoirs and useful
tools for understanding calcium homeostasis in eggs that express both types of receptors.
acid behaviour in Bufo arenarum egg activation. The concerted action of arachidonic acid and/or its
metabolites could provide controlled mobilization of calcium from intracellular reservoirs and useful
tools for understanding calcium homeostasis in eggs that express both types of receptors.
metabolites could provide controlled mobilization of calcium from intracellular reservoirs and useful
tools for understanding calcium homeostasis in eggs that express both types of receptors.
PLA2 reaction metabolite, was able to induce activation events in a bell-shaped manner. Differential
regulation of IP3Rs and RyRs by arachidonic acid and its products could explainmelittin and arachidonic
acid behaviour in Bufo arenarum egg activation. The concerted action of arachidonic acid and/or its
metabolites could provide controlled mobilization of calcium from intracellular reservoirs and useful
tools for understanding calcium homeostasis in eggs that express both types of receptors.
metabolites could provide controlled mobilization of calcium from intracellular reservoirs and useful
tools for understanding calcium homeostasis in eggs that express both types of receptors.
acid behaviour in Bufo arenarum egg activation. The concerted action of arachidonic acid and/or its
metabolites could provide controlled mobilization of calcium from intracellular reservoirs and useful
tools for understanding calcium homeostasis in eggs that express both types of receptors.
metabolites could provide controlled mobilization of calcium from intracellular reservoirs and useful
tools for understanding calcium homeostasis in eggs that express both types of receptors.
regulation of IP3Rs and RyRs by arachidonic acid and its products could explainmelittin and arachidonic
acid behaviour in Bufo arenarum egg activation. The concerted action of arachidonic acid and/or its
metabolites could provide controlled mobilization of calcium from intracellular reservoirs and useful
tools for understanding calcium homeostasis in eggs that express both types of receptors.
metabolites could provide controlled mobilization of calcium from intracellular reservoirs and useful
tools for understanding calcium homeostasis in eggs that express both types of receptors.
acid behaviour in Bufo arenarum egg activation. The concerted action of arachidonic acid and/or its
metabolites could provide controlled mobilization of calcium from intracellular reservoirs and useful
tools for understanding calcium homeostasis in eggs that express both types of receptors.
metabolites could provide controlled mobilization of calcium from intracellular reservoirs and useful
tools for understanding calcium homeostasis in eggs that express both types of receptors.
in the process of Bufo arenarum oocyte activation and the interrelation between any of its metabolites
and the ion channels involved in the calcium release from the intracellular reservoirs at fertilization.
We found that addition of both melittin, a potent PLA2 activator, and arachidonic acid, the main
PLA2 reaction metabolite, was able to induce activation events in a bell-shaped manner. Differential
regulation of IP3Rs and RyRs by arachidonic acid and its products could explainmelittin and arachidonic
acid behaviour in Bufo arenarum egg activation. The concerted action of arachidonic acid and/or its
metabolites could provide controlled mobilization of calcium from intracellular reservoirs and useful
tools for understanding calcium homeostasis in eggs that express both types of receptors.
metabolites could provide controlled mobilization of calcium from intracellular reservoirs and useful
tools for understanding calcium homeostasis in eggs that express both types of receptors.
acid behaviour in Bufo arenarum egg activation. The concerted action of arachidonic acid and/or its
metabolites could provide controlled mobilization of calcium from intracellular reservoirs and useful
tools for understanding calcium homeostasis in eggs that express both types of receptors.
metabolites could provide controlled mobilization of calcium from intracellular reservoirs and useful
tools for understanding calcium homeostasis in eggs that express both types of receptors.
regulation of IP3Rs and RyRs by arachidonic acid and its products could explainmelittin and arachidonic
acid behaviour in Bufo arenarum egg activation. The concerted action of arachidonic acid and/or its
metabolites could provide controlled mobilization of calcium from intracellular reservoirs and useful
tools for understanding calcium homeostasis in eggs that express both types of receptors.
metabolites could provide controlled mobilization of calcium from intracellular reservoirs and useful
tools for understanding calcium homeostasis in eggs that express both types of receptors.
acid behaviour in Bufo arenarum egg activation. The concerted action of arachidonic acid and/or its
metabolites could provide controlled mobilization of calcium from intracellular reservoirs and useful
tools for understanding calcium homeostasis in eggs that express both types of receptors.
metabolites could provide controlled mobilization of calcium from intracellular reservoirs and useful
tools for understanding calcium homeostasis in eggs that express both types of receptors.
PLA2 reaction metabolite, was able to induce activation events in a bell-shaped manner. Differential
regulation of IP3Rs and RyRs by arachidonic acid and its products could explainmelittin and arachidonic
acid behaviour in Bufo arenarum egg activation. The concerted action of arachidonic acid and/or its
metabolites could provide controlled mobilization of calcium from intracellular reservoirs and useful
tools for understanding calcium homeostasis in eggs that express both types of receptors.
metabolites could provide controlled mobilization of calcium from intracellular reservoirs and useful
tools for understanding calcium homeostasis in eggs that express both types of receptors.
acid behaviour in Bufo arenarum egg activation. The concerted action of arachidonic acid and/or its
metabolites could provide controlled mobilization of calcium from intracellular reservoirs and useful
tools for understanding calcium homeostasis in eggs that express both types of receptors.
metabolites could provide controlled mobilization of calcium from intracellular reservoirs and useful
tools for understanding calcium homeostasis in eggs that express both types of receptors.
regulation of IP3Rs and RyRs by arachidonic acid and its products could explainmelittin and arachidonic
acid behaviour in Bufo arenarum egg activation. The concerted action of arachidonic acid and/or its
metabolites could provide controlled mobilization of calcium from intracellular reservoirs and useful
tools for understanding calcium homeostasis in eggs that express both types of receptors.
metabolites could provide controlled mobilization of calcium from intracellular reservoirs and useful
tools for understanding calcium homeostasis in eggs that express both types of receptors.
acid behaviour in Bufo arenarum egg activation. The concerted action of arachidonic acid and/or its
metabolites could provide controlled mobilization of calcium from intracellular reservoirs and useful
tools for understanding calcium homeostasis in eggs that express both types of receptors.
metabolites could provide controlled mobilization of calcium from intracellular reservoirs and useful
tools for understanding calcium homeostasis in eggs that express both types of receptors.
and the ion channels involved in the calcium release from the intracellular reservoirs at fertilization.
We found that addition of both melittin, a potent PLA2 activator, and arachidonic acid, the main
PLA2 reaction metabolite, was able to induce activation events in a bell-shaped manner. Differential
regulation of IP3Rs and RyRs by arachidonic acid and its products could explainmelittin and arachidonic
acid behaviour in Bufo arenarum egg activation. The concerted action of arachidonic acid and/or its
metabolites could provide controlled mobilization of calcium from intracellular reservoirs and useful
tools for understanding calcium homeostasis in eggs that express both types of receptors.
metabolites could provide controlled mobilization of calcium from intracellular reservoirs and useful
tools for understanding calcium homeostasis in eggs that express both types of receptors.
acid behaviour in Bufo arenarum egg activation. The concerted action of arachidonic acid and/or its
metabolites could provide controlled mobilization of calcium from intracellular reservoirs and useful
tools for understanding calcium homeostasis in eggs that express both types of receptors.
metabolites could provide controlled mobilization of calcium from intracellular reservoirs and useful
tools for understanding calcium homeostasis in eggs that express both types of receptors.
regulation of IP3Rs and RyRs by arachidonic acid and its products could explainmelittin and arachidonic
acid behaviour in Bufo arenarum egg activation. The concerted action of arachidonic acid and/or its
metabolites could provide controlled mobilization of calcium from intracellular reservoirs and useful
tools for understanding calcium homeostasis in eggs that express both types of receptors.
metabolites could provide controlled mobilization of calcium from intracellular reservoirs and useful
tools for understanding calcium homeostasis in eggs that express both types of receptors.
acid behaviour in Bufo arenarum egg activation. The concerted action of arachidonic acid and/or its
metabolites could provide controlled mobilization of calcium from intracellular reservoirs and useful
tools for understanding calcium homeostasis in eggs that express both types of receptors.
metabolites could provide controlled mobilization of calcium from intracellular reservoirs and useful
tools for understanding calcium homeostasis in eggs that express both types of receptors.
PLA2 reaction metabolite, was able to induce activation events in a bell-shaped manner. Differential
regulation of IP3Rs and RyRs by arachidonic acid and its products could explainmelittin and arachidonic
acid behaviour in Bufo arenarum egg activation. The concerted action of arachidonic acid and/or its
metabolites could provide controlled mobilization of calcium from intracellular reservoirs and useful
tools for understanding calcium homeostasis in eggs that express both types of receptors.
metabolites could provide controlled mobilization of calcium from intracellular reservoirs and useful
tools for understanding calcium homeostasis in eggs that express both types of receptors.
acid behaviour in Bufo arenarum egg activation. The concerted action of arachidonic acid and/or its
metabolites could provide controlled mobilization of calcium from intracellular reservoirs and useful
tools for understanding calcium homeostasis in eggs that express both types of receptors.
metabolites could provide controlled mobilization of calcium from intracellular reservoirs and useful
tools for understanding calcium homeostasis in eggs that express both types of receptors.
regulation of IP3Rs and RyRs by arachidonic acid and its products could explainmelittin and arachidonic
acid behaviour in Bufo arenarum egg activation. The concerted action of arachidonic acid and/or its
metabolites could provide controlled mobilization of calcium from intracellular reservoirs and useful
tools for understanding calcium homeostasis in eggs that express both types of receptors.
metabolites could provide controlled mobilization of calcium from intracellular reservoirs and useful
tools for understanding calcium homeostasis in eggs that express both types of receptors.
acid behaviour in Bufo arenarum egg activation. The concerted action of arachidonic acid and/or its
metabolites could provide controlled mobilization of calcium from intracellular reservoirs and useful
tools for understanding calcium homeostasis in eggs that express both types of receptors.
metabolites could provide controlled mobilization of calcium from intracellular reservoirs and useful
tools for understanding calcium homeostasis in eggs that express both types of receptors.
endoplasmic reticulum as well as from the nuclear envelope. Previous studies have suggested that
arachidonic acid and/or its metabolites were able to modulate the activity of several ion channels.
Based on these findings, we have studied the participation of the phospholipase A2 (PLA2) pathway
in the process of Bufo arenarum oocyte activation and the interrelation between any of its metabolites
and the ion channels involved in the calcium release from the intracellular reservoirs at fertilization.
We found that addition of both melittin, a potent PLA2 activator, and arachidonic acid, the main
PLA2 reaction metabolite, was able to induce activation events in a bell-shaped manner. Differential
regulation of IP3Rs and RyRs by arachidonic acid and its products could explainmelittin and arachidonic
acid behaviour in Bufo arenarum egg activation. The concerted action of arachidonic acid and/or its
metabolites could provide controlled mobilization of calcium from intracellular reservoirs and useful
tools for understanding calcium homeostasis in eggs that express both types of receptors.
metabolites could provide controlled mobilization of calcium from intracellular reservoirs and useful
tools for understanding calcium homeostasis in eggs that express both types of receptors.
acid behaviour in Bufo arenarum egg activation. The concerted action of arachidonic acid and/or its
metabolites could provide controlled mobilization of calcium from intracellular reservoirs and useful
tools for understanding calcium homeostasis in eggs that express both types of receptors.
metabolites could provide controlled mobilization of calcium from intracellular reservoirs and useful
tools for understanding calcium homeostasis in eggs that express both types of receptors.
regulation of IP3Rs and RyRs by arachidonic acid and its products could explainmelittin and arachidonic
acid behaviour in Bufo arenarum egg activation. The concerted action of arachidonic acid and/or its
metabolites could provide controlled mobilization of calcium from intracellular reservoirs and useful
tools for understanding calcium homeostasis in eggs that express both types of receptors.
metabolites could provide controlled mobilization of calcium from intracellular reservoirs and useful
tools for understanding calcium homeostasis in eggs that express both types of receptors.
acid behaviour in Bufo arenarum egg activation. The concerted action of arachidonic acid and/or its
metabolites could provide controlled mobilization of calcium from intracellular reservoirs and useful
tools for understanding calcium homeostasis in eggs that express both types of receptors.
metabolites could provide controlled mobilization of calcium from intracellular reservoirs and useful
tools for understanding calcium homeostasis in eggs that express both types of receptors.
PLA2 reaction metabolite, was able to induce activation events in a bell-shaped manner. Differential
regulation of IP3Rs and RyRs by arachidonic acid and its products could explainmelittin and arachidonic
acid behaviour in Bufo arenarum egg activation. The concerted action of arachidonic acid and/or its
metabolites could provide controlled mobilization of calcium from intracellular reservoirs and useful
tools for understanding calcium homeostasis in eggs that express both types of receptors.
metabolites could provide controlled mobilization of calcium from intracellular reservoirs and useful
tools for understanding calcium homeostasis in eggs that express both types of receptors.
acid behaviour in Bufo arenarum egg activation. The concerted action of arachidonic acid and/or its
metabolites could provide controlled mobilization of calcium from intracellular reservoirs and useful
tools for understanding calcium homeostasis in eggs that express both types of receptors.
metabolites could provide controlled mobilization of calcium from intracellular reservoirs and useful
tools for understanding calcium homeostasis in eggs that express both types of receptors.
regulation of IP3Rs and RyRs by arachidonic acid and its products could explainmelittin and arachidonic
acid behaviour in Bufo arenarum egg activation. The concerted action of arachidonic acid and/or its
metabolites could provide controlled mobilization of calcium from intracellular reservoirs and useful
tools for understanding calcium homeostasis in eggs that express both types of receptors.
metabolites could provide controlled mobilization of calcium from intracellular reservoirs and useful
tools for understanding calcium homeostasis in eggs that express both types of receptors.
acid behaviour in Bufo arenarum egg activation. The concerted action of arachidonic acid and/or its
metabolites could provide controlled mobilization of calcium from intracellular reservoirs and useful
tools for understanding calcium homeostasis in eggs that express both types of receptors.
metabolites could provide controlled mobilization of calcium from intracellular reservoirs and useful
tools for understanding calcium homeostasis in eggs that express both types of receptors.
and the ion channels involved in the calcium release from the intracellular reservoirs at fertilization.
We found that addition of both melittin, a potent PLA2 activator, and arachidonic acid, the main
PLA2 reaction metabolite, was able to induce activation events in a bell-shaped manner. Differential
regulation of IP3Rs and RyRs by arachidonic acid and its products could explainmelittin and arachidonic
acid behaviour in Bufo arenarum egg activation. The concerted action of arachidonic acid and/or its
metabolites could provide controlled mobilization of calcium from intracellular reservoirs and useful
tools for understanding calcium homeostasis in eggs that express both types of receptors.
metabolites could provide controlled mobilization of calcium from intracellular reservoirs and useful
tools for understanding calcium homeostasis in eggs that express both types of receptors.
acid behaviour in Bufo arenarum egg activation. The concerted action of arachidonic acid and/or its
metabolites could provide controlled mobilization of calcium from intracellular reservoirs and useful
tools for understanding calcium homeostasis in eggs that express both types of receptors.
metabolites could provide controlled mobilization of calcium from intracellular reservoirs and useful
tools for understanding calcium homeostasis in eggs that express both types of receptors.
regulation of IP3Rs and RyRs by arachidonic acid and its products could explainmelittin and arachidonic
acid behaviour in Bufo arenarum egg activation. The concerted action of arachidonic acid and/or its
metabolites could provide controlled mobilization of calcium from intracellular reservoirs and useful
tools for understanding calcium homeostasis in eggs that express both types of receptors.
metabolites could provide controlled mobilization of calcium from intracellular reservoirs and useful
tools for understanding calcium homeostasis in eggs that express both types of receptors.
acid behaviour in Bufo arenarum egg activation. The concerted action of arachidonic acid and/or its
metabolites could provide controlled mobilization of calcium from intracellular reservoirs and useful
tools for understanding calcium homeostasis in eggs that express both types of receptors.
metabolites could provide controlled mobilization of calcium from intracellular reservoirs and useful
tools for understanding calcium homeostasis in eggs that express both types of receptors.
PLA2 reaction metabolite, was able to induce activation events in a bell-shaped manner. Differential
regulation of IP3Rs and RyRs by arachidonic acid and its products could explainmelittin and arachidonic
acid behaviour in Bufo arenarum egg activation. The concerted action of arachidonic acid and/or its
metabolites could provide controlled mobilization of calcium from intracellular reservoirs and useful
tools for understanding calcium homeostasis in eggs that express both types of receptors.
metabolites could provide controlled mobilization of calcium from intracellular reservoirs and useful
tools for understanding calcium homeostasis in eggs that express both types of receptors.
acid behaviour in Bufo arenarum egg activation. The concerted action of arachidonic acid and/or its
metabolites could provide controlled mobilization of calcium from intracellular reservoirs and useful
tools for understanding calcium homeostasis in eggs that express both types of receptors.
metabolites could provide controlled mobilization of calcium from intracellular reservoirs and useful
tools for understanding calcium homeostasis in eggs that express both types of receptors.
regulation of IP3Rs and RyRs by arachidonic acid and its products could explainmelittin and arachidonic
acid behaviour in Bufo arenarum egg activation. The concerted action of arachidonic acid and/or its
metabolites could provide controlled mobilization of calcium from intracellular reservoirs and useful
tools for understanding calcium homeostasis in eggs that express both types of receptors.
metabolites could provide controlled mobilization of calcium from intracellular reservoirs and useful
tools for understanding calcium homeostasis in eggs that express both types of receptors.
acid behaviour in Bufo arenarum egg activation. The concerted action of arachidonic acid and/or its
metabolites could provide controlled mobilization of calcium from intracellular reservoirs and useful
tools for understanding calcium homeostasis in eggs that express both types of receptors.
metabolites could provide controlled mobilization of calcium from intracellular reservoirs and useful
tools for understanding calcium homeostasis in eggs that express both types of receptors.
in the process of Bufo arenarum oocyte activation and the interrelation between any of its metabolites
and the ion channels involved in the calcium release from the intracellular reservoirs at fertilization.
We found that addition of both melittin, a potent PLA2 activator, and arachidonic acid, the main
PLA2 reaction metabolite, was able to induce activation events in a bell-shaped manner. Differential
regulation of IP3Rs and RyRs by arachidonic acid and its products could explainmelittin and arachidonic
acid behaviour in Bufo arenarum egg activation. The concerted action of arachidonic acid and/or its
metabolites could provide controlled mobilization of calcium from intracellular reservoirs and useful
tools for understanding calcium homeostasis in eggs that express both types of receptors.
metabolites could provide controlled mobilization of calcium from intracellular reservoirs and useful
tools for understanding calcium homeostasis in eggs that express both types of receptors.
acid behaviour in Bufo arenarum egg activation. The concerted action of arachidonic acid and/or its
metabolites could provide controlled mobilization of calcium from intracellular reservoirs and useful
tools for understanding calcium homeostasis in eggs that express both types of receptors.
metabolites could provide controlled mobilization of calcium from intracellular reservoirs and useful
tools for understanding calcium homeostasis in eggs that express both types of receptors.
regulation of IP3Rs and RyRs by arachidonic acid and its products could explainmelittin and arachidonic
acid behaviour in Bufo arenarum egg activation. The concerted action of arachidonic acid and/or its
metabolites could provide controlled mobilization of calcium from intracellular reservoirs and useful
tools for understanding calcium homeostasis in eggs that express both types of receptors.
metabolites could provide controlled mobilization of calcium from intracellular reservoirs and useful
tools for understanding calcium homeostasis in eggs that express both types of receptors.
acid behaviour in Bufo arenarum egg activation. The concerted action of arachidonic acid and/or its
metabolites could provide controlled mobilization of calcium from intracellular reservoirs and useful
tools for understanding calcium homeostasis in eggs that express both types of receptors.
metabolites could provide controlled mobilization of calcium from intracellular reservoirs and useful
tools for understanding calcium homeostasis in eggs that express both types of receptors.
PLA2 reaction metabolite, was able to induce activation events in a bell-shaped manner. Differential
regulation of IP3Rs and RyRs by arachidonic acid and its products could explainmelittin and arachidonic
acid behaviour in Bufo arenarum egg activation. The concerted action of arachidonic acid and/or its
metabolites could provide controlled mobilization of calcium from intracellular reservoirs and useful
tools for understanding calcium homeostasis in eggs that express both types of receptors.
metabolites could provide controlled mobilization of calcium from intracellular reservoirs and useful
tools for understanding calcium homeostasis in eggs that express both types of receptors.
acid behaviour in Bufo arenarum egg activation. The concerted action of arachidonic acid and/or its
metabolites could provide controlled mobilization of calcium from intracellular reservoirs and useful
tools for understanding calcium homeostasis in eggs that express both types of receptors.
metabolites could provide controlled mobilization of calcium from intracellular reservoirs and useful
tools for understanding calcium homeostasis in eggs that express both types of receptors.
regulation of IP3Rs and RyRs by arachidonic acid and its products could explainmelittin and arachidonic
acid behaviour in Bufo arenarum egg activation. The concerted action of arachidonic acid and/or its
metabolites could provide controlled mobilization of calcium from intracellular reservoirs and useful
tools for understanding calcium homeostasis in eggs that express both types of receptors.
metabolites could provide controlled mobilization of calcium from intracellular reservoirs and useful
tools for understanding calcium homeostasis in eggs that express both types of receptors.
acid behaviour in Bufo arenarum egg activation. The concerted action of arachidonic acid and/or its
metabolites could provide controlled mobilization of calcium from intracellular reservoirs and useful
tools for understanding calcium homeostasis in eggs that express both types of receptors.
metabolites could provide controlled mobilization of calcium from intracellular reservoirs and useful
tools for understanding calcium homeostasis in eggs that express both types of receptors.
and the ion channels involved in the calcium release from the intracellular reservoirs at fertilization.
We found that addition of both melittin, a potent PLA2 activator, and arachidonic acid, the main
PLA2 reaction metabolite, was able to induce activation events in a bell-shaped manner. Differential
regulation of IP3Rs and RyRs by arachidonic acid and its products could explainmelittin and arachidonic
acid behaviour in Bufo arenarum egg activation. The concerted action of arachidonic acid and/or its
metabolites could provide controlled mobilization of calcium from intracellular reservoirs and useful
tools for understanding calcium homeostasis in eggs that express both types of receptors.
metabolites could provide controlled mobilization of calcium from intracellular reservoirs and useful
tools for understanding calcium homeostasis in eggs that express both types of receptors.
acid behaviour in Bufo arenarum egg activation. The concerted action of arachidonic acid and/or its
metabolites could provide controlled mobilization of calcium from intracellular reservoirs and useful
tools for understanding calcium homeostasis in eggs that express both types of receptors.
metabolites could provide controlled mobilization of calcium from intracellular reservoirs and useful
tools for understanding calcium homeostasis in eggs that express both types of receptors.
regulation of IP3