RAC-3 is a NF-?B coactivator

WERBAJH S E; NOJEK I; LANZ, R.; MONICA ALEJANDRA COSTAS

Febs Letters

Año: 2000 vol. 485 p. 195 - 199

0014-5793

It has been shown that the molecular mechanism by which cytokines and glucocorticoids mutually antagonize their functions involves a mutual glucocorticoid receptor (GR)/nuclear factor-UB (NF-UB) transrepression. Here we report a role for the nuclear receptor coactivator RAC3, in modulating NF-UB transactivation. We found that RAC3 functions as a coactivator by binding to the active form of NF-UB and that overexpression of RAC3 restores GR-dependent transcription neglecting GR/ NF-UB transrepression. The competition between GR and NF- UB for binding to RAC3 may represent a general mechanism by which both transcription factors mutually antagonize their activity. fl 2000 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.