Structural, spectral and potentiometric characterization and antimicrobial activity studies of the new Zn(II) complex: [Zn(phen)2(cnge)(H2O)](NO3)2.H2O

L. L. LÓPEZ TÉVEZ; M. S. ISLAS; J. J. MARTÍNEZ MEDINA; M. DIEZA; O. E. PIRO; E. E. CASTELLANO; E. G. FERRER; P. A. M. WILLIAMS

JOURNAL OF COORDINATION CHEMISTRY

TAYLOR & FRANCIS LTD

Año: 2012 vol. 65 p. 2304 - 2318

0095-8972

The octahedral Zn complex with o-phenanthroline (o-phen) and cyanoguanidine (cnge) has been synthesized and characterized. The crystal structural data show the formation of a ZnN5O core where the metal coordinates to two mutually perpendicular ophenanthroline molecules acting as bidentate ligands through their N-atoms [Zn-N bond lengths in the 2.124(2)-2.193(2) Å range], the cyanide nitrogen of a cnge molecule [d(Zn-N) = 2.092(2) Å, (Zn-N-C)=161.1(2)°] and a water molecule [d(Zn-Ow) = 2.112(2) Å]. Spectral data (FTIR, Raman and fluorescence) and speciation studies are in agreement with the structure found in the solid state and the one proposed to exist in solution. To evaluate the changes in the microbiological activity of Zn, antibacterial studies were carried out by observing the changes in MIC (minimum inhibitory concentration) of the complex, the ligands and the metal against five different bacterial strains. The antibacterial activity of Zn was found to improve upon complexation in three of the tested strains.5O core where the metal coordinates to two mutually perpendicular ophenanthroline molecules acting as bidentate ligands through their N-atoms [Zn-N bond lengths in the 2.124(2)-2.193(2) Å range], the cyanide nitrogen of a cnge molecule [d(Zn-N) = 2.092(2) Å, (Zn-N-C)=161.1(2)°] and a water molecule [d(Zn-Ow) = 2.112(2) Å]. Spectral data (FTIR, Raman and fluorescence) and speciation studies are in agreement with the structure found in the solid state and the one proposed to exist in solution. To evaluate the changes in the microbiological activity of Zn, antibacterial studies were carried out by observing the changes in MIC (minimum inhibitory concentration) of the complex, the ligands and the metal against five different bacterial strains. The antibacterial activity of Zn was found to improve upon complexation in three of the tested strains.