The cAMP-PKA signalling crosstalks with CWI and HOG-MAPK pathways in yeast cell response to osmotic and thermal stress

GALELLO, FIORELLA; BERMÚDEZ-MORETTI, MARIANA; ORTOLÁ MARTÍNEZ, MARÍA CLARA; ROSSI, SILVIA; PORTELA, PAULA

Microbial Cell

Shared Science Publishers OG

Año: 2024 vol. 11 p. 90 - 105

The yeast Saccharomyces cerevisiae is widely used infood and non-food industries. During industrial fermentation yeaststrains are exposed to fluctuations in oxygen concentration, osmotic pressure, pH, ethanol concentration, nutrient availability andtemperature. Fermentation performance depends on the ability ofthe yeast strains to adapt to these changes. Suboptimal conditionstrigger responses to the external stimuli to allow homeostasis to bemaintained. Stress-specific signalling pathways are activated to coordinate changes in transcription, translation, protein function, andmetabolic fluxes while a transient arrest of growth and cell cycleprogression occur. cAMP-PKA, HOG-MAPK and CWI signalling pathways are turned on during stress response. Comprehension of themechanisms involved in the responses and in the adaptation tothese stresses during fermentation is key to improving this industrial process. The scope of this review is to outline the advancementof knowledge about the cAMP-PKA signalling and the crosstalk ofthis pathway with the CWI and HOG-MAPK cascades in response tothe environmental challenges heat and hyperosmotic stress.