Cyclocondensation versus Cyclocondensation Plus Dehydroxylation During the Reaction of Flavones and Hydrazine

SOLIS, CARLOS M; SALAZAR, MARIO O; RAMALLO, I AYELEN; FURLAN, RICADO L E

European Journal of Organic Chemistry

John Wiley and Sons Inc

Año: 2022 vol. 2022

Concomitant selective dehydroxylation during the transformation of flavones into pyrazoles with hydrazine is determined by the A-ring substitution pattern and propensity to keto enol tautomerization. The obtained pyrazoles show varied tyrosinase inhibition properties, including one nanomolar inhibitor.