Editorial: New advances on hypothalamus-pituitary stem cell biology

CHEUNG L; DAVIS SW; PEREZ MILLAN MI

Frontiers in Endocrinology

Frontiers Media SA

Año: 2024 vol. 15

The discovery of stem cells in many tissues including the pituitary and hypothalamus has presented the potential for stem cell regeneration and treatment for human diseases. However, significant gaps in knowledge remain in our understanding of the full range of molecular mechanisms that regulate the progression of these stem cells into the desired cell-types, limiting the translatability of basic science into human therapies. The articles in this Research Topic present novel data and review recent discoveries from a combination of human genetic studies, human organoid models and mouse models to improve our understanding of hypothalamic-pituitary stem cell regulation.