Leukocyte telomere length is associated with iron overload in male adults with hereditary hemochromatosis

MAXIMILINO MARTÍN; ANDREA LILIANA MILLÁN; FLORENCIA FERRARO; WALTER TETZLAFF; ELIANA BOTTA; MARCELO CASTRO; LAURA BOERO; JORGE REY; JORGE DARUICH; GUSTAVO FRECHTEL; TOMAS MEROÑO; GLORIA EDITH CERRONE; FERNANDO BRITES

BIOSCIENCE REPORTS

PORTLAND PRESS LTD

Lugar: Londres; Año: 2020

0144-8463

Background: Hereditary hemochromatosis (HH) is a primary iron overload (IO) condition.Absolute telomere length (ATL) is a marker of cellular aging and DNA damage associatedwith chronic diseases and mortality.Aim: To evaluate the relationship between ATL and IO in patients with HH.Methods: Cross-sectional study including 25 patients with HH: 8 with IO and 17 without IO(ferritin < 300 ng/ml) and 25 healthy controls. Inclusion criteria were: age > 18 years, malesex and HH diagnosis. Patients with diabetes or other endocrine and autoimmune diseaseswere excluded. ATL was measured by real-time PCR.Results: HH patients with IO were older (P