INVESTIGADORES
GARRO MARTINEZ Juan Ceferino
artículos
Título:
Anticonvulsant Activity of Ringed Enaminones: A QSAR Study
Autor/es:
JUAN C. GARRO MARTINEZ; PABLO R. DUCHOWICZ; M. R. ESTRADA; GRACIELA N. ZAMARBIDE; E. A. CASTRO
Revista:
QSAR Comb. Sci
Referencias:
Año: 2009 vol. 28 p. 1376 - 1385
Resumen:
Abstract: The formalism of the QSAR Theory is employed to establish mathematical relationships
that link the molecular structure of ringed enaminones to their observed antiepileptic activity. The
design of predictive linear regression models, solely based on the available experimental
information, involved the simultaneous analysis of 1312 theoretical descriptors calculated with
Dragon software. This QSAR study that is based both on classic antiepileptics and secondgeneration
anticonvulsant drugs, including compounds of the enaminone type, allowed the
proposal of novel ringed enaminone derivatives as possible antiepileptic agents, posing a similar or
even better predicted biological activity when compared to other commonly used drugs.