Long-term analysis of antibodies elicited by SPUTNIK V: A prospective cohort study in Tucumán, Argentina

CHAHLA, ROSSANA ELENA; TOMAS-GRAU, RODRIGO HERNÁN; CAZORLA, SILVIA INÉS; PLOPER, DIEGO; VERA PINGITORE, ESTEBAN; LÓPEZ, MÓNICA AGUILAR; AZNAR, PATRICIA; ALCORTA, MARÍA ELENA; VÉLEZ, EVA MARÍA DEL MAR; STAGNETTO, AGUSTÍN; ÁVILA, CÉSAR LUÍS; MALDONADO-GALDEANO, CAROLINA; SOCIAS, SERGIO BENJAMÍN; HEINZE, DAR; NAVARRO, SILVIA ADRIANA; LLAPUR, CONRADO JUAN; COSTA, DARDO; FLORES, ISOLINA; EDELSTEIN, ALEXIS; KOWDLE, SHREYAS; PERANDONES, CLAUDIA; LEE, BENHUR; APFELBAUM, GABRIELA; MOSTOSLAVSKY, RAÚL; MOSTOSLAVSKY, GUSTAVO; PERDIGÓN, GABRIELA; CHEHÍN, ROSANA NIEVES

The Lancet Regional Health - Americas

Elsevier

Año: 2022 vol. 6 p. 1 - 14

2667-193X

SummaryBackground Gam-COVID-Vac (SPUTNIK V) has been granted emergency use authorization in 70 nations and hasbeen administered to millions worldwide. However, there are very few peer-reviewed studies describing its effects.Independent reports regarding safety and effectiveness could accelerate the final approval by the WHO. We aimedto study the long-term humoral immune response in nay¨ve and previously infected volunteers who received SPUTNIK V.Methods Humoral immune responses, assayed by anti-SARS-CoV-2-spike-RBD IgG ELISA and neutralizationassays, were measured in 602 healthcare workers at 0, 14, 28, 60 and 180 days after receiving SPUTNIK V betweenDecember 2020 and July 2021 in Tucuman, Argentina.Findings Seroconversion was detected in 97% of individuals after 28 days post-vaccination (dpv) (N = 405). AntiRBD titers began to decrease after 60 dpv (N = 328), but remained detectable in 94% at 90 dpv (N = 224). At 180dpv, anti-RDB titers persisted in 31% (N = 146). Previous infection triggered an increased immune response to thefirst dose and increased neutralization activity against variants of concern (VOC). Second doses in previouslyinfected individuals further increased titers, even 90 dpv (N = 75). Basal antibody titers had more influence on postvaccination anti-RBD responses than the time elapsed between diagnosis and vaccination (N = 274).Interpretation Data presented herein provides essential knowledge regarding the kinetics of antibodies induced bySPUTNIK V up to six months after immunization, and suggests that when considering one-dose vaccination policiesfor individuals with previous SARS-CoV-2 infection, serological studies to determine basal titers may be important,independent of when diagnosis occurred