INVESTIGADORES
GOICOECHEA Hector Casimiro
artículos
Título:
Simultaneous multivariate spectrophotometric analysis of paracetamol and minor components (diphenhydramine or phenylpropanolamine) in tablet preparations
Autor/es:
GOICOECHEA, HÉCTOR C; AC OLIVIERI,
Revista:
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
Editorial:
Elsevier
Referencias:
Año: 1999 vol. 20 p. 255 - 261
ISSN:
0731-7085
Resumen:
The use of multivariate spectrophotometric calibration is reported for the analysis of two decongestant tablets,
where paracetamol is the principal component and diphenhydramine or phenylpropanolamine are the minor
components. The resolution of these mixtures has been accomplished without prior separation or derivatisation, by
using partial least-squares (PLS-1) regression analysis of electronic absorption spectral data. Although the molar
ratios of paracetamol to the minor components were 38:1 and 25:1 respectively, the latter have been determined with
high accuracy and precision, and with no interference from tablet excipients. PLS is able to take into account small
deviations of paracetamol from linearity in the studied concentration range. The application of classical least-squares
(CLS) analysis yields unsatisfactory results, due to the low absorbances of the minor components within the range
where all components obey Beers law.