Fever-like temperature impacts on Staphylococcus aureus and Pseudomonas aeruginosa interaction, physiology, and virulence both in vitro and in vivo

SOLAR VENERO ESMERALDA C.; GALEANO MARIANA BELEN; LUQMAN, ARIF; RICARDI MARTINIANO M; SERRAL FEDERICO; FERNANDEZ DO PORTO DARIO; ROBALDI STEFANIA; ASHARI BAZ; MUNIF TH; EGOBURO DE; NEMIROVSKY SERGIO; ESCALANTE JENNY; NISHIMURA BRENT; RAMIREZ MARIA SOLEDAD; GOTZ F; PAULA M. TRIBELLI

BMC BIOLOGY

BIOMED CENTRAL LTD

Año: 2024 vol. 22

1741-7007

Staphylococcus aureus (SA) and Pseudomonas aeruginosa (PA) cause a wide variety of bacterial infections and coinfections, showing a complex interaction that involves the production of different metabolites and metabolic changes. Temperature is a key factor for bacterial survival and virulence and within the host, bacteria could be exposed to an increment in temperature during fever development. We analyzed the previously unexplored effect of fever-like temperatures (39 °C) on S. aureus USA300 and P. aeruginosa PAO1 microaerobic mono- and co-cultures compared with 37 °C, by using RNAseq and physiological assays including in vivo experiments.