INVESTIGADORES
PORTELA Paula
artículos
Título:
The cAMP-PKA signalling crosstalks with CWI and HOG-MAPK pathways in yeast cell response to osmotic and thermal stress
Autor/es:
GALELLO, FIORELLA; BERMÚDEZ-MORETTI, MARIANA; ORTOLÁ MARTÍNEZ, MARÍA CLARA; ROSSI, SILVIA; PORTELA, PAULA
Revista:
Microbial Cell
Editorial:
Shared Science Publishers (SSP) GmbH
Referencias:
Año: 2024 vol. 11 p. 90 - 105
Resumen:
The yeast Saccharomyces cerevisiae is widely used in food and non-food industries. During industrial fermentation yeast strains are exposed to fluctuations in oxygen concentration, osmoticpressure, pH, ethanol concentration, nutrient availability and temperature. Fermentation performance depends on the ability of the yeast strains to adapt to these changes. Suboptimal conditions trigger responses to the external stimuli to allow homeostasis to bemaintained. Stress-specific signalling pathways are activated to coordinatechanges in transcription, translation, protein function, and metabolic fluxes while a transient arrest of growth and cell cycle progression occur. cAMP-PKA, HOG-MAPK and CWI signalling pathwaysare turned on during stress response. Comprehension of the mechanisms involved in the responses and in the adaptation to these stresses during fermentation is key to improving this industrial process. The scope of this review is to outline the advancement of knowledge about the cAMP-PKA signalling and the crosstalk of this pathway with the CWI and HOG-MAPK cascades in response tothe environmental challenges heat and hyperosmotic stress.