INVESTIGADORES
MARTINEZ nora Alicia
artículos
Título:
Aquaporins in Fetal Development
Autor/es:
MARTÍNEZ NORA; DAMIANO ALICIA
Revista:
ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY.
Editorial:
SPRINGER-VERLAG BERLIN
Referencias:
Año: 2023
ISSN:
0065-2598
Resumen:
Water homeostasis is essential for fetal growth, and it depends on thesuccessful development of the placenta. Many aquaporins (AQPs) wereidentified from blastocyst stages to term placenta. In the last years,cytokines, hormones, second messengers, intracellular pH, and membraneproteins were found to regulate their expression and function in the humanplacenta and fetal membranes. Accumulated data suggest that these proteinsmay be involved not only in the maintenance of the amniotic fluid volumehomeostasis but also in the development of the placenta and fetal organs. Inthis sense, dysregulation of placental AQPs is associated with gestationaldisorders. Thus, current evidence shows that AQPs may collaborate incellular events including trophoblast migration and apoptosis. In addition,aquaglyceroporins are involved in energy metabolism as well as ureaelimination across the placenta. In the last year, the presence of AQP9 introphoblast mitochondria opened new hypotheses about its role in pregnancy. However, much further work is needed to understand theimportance of these proteins in human pregnancies.
